77876-73-4

Upstream product

• 591-50-4 iodobenzene 
• 1227747-59-2 2-(4-methoxyphenyl)-4-methyloxazole-5-carboxylic acid 
• 132353-25-4 2-(4-methoxybenzoyloxy)-4,6-dimethoxy-1,3,5-triazine 
• 100-09-4 4-methoxybenzoic acid 
• 98-80-6 phenylboronic acid 
• 119-51-7 1-phenyl-1,2-propanedione 2-oxime 
• 123-11-5 4-methoxy-benzaldehyde 

Relevant academic research and scientific papers

Development of a method for the synthesis of 2,4,5-trisubstituted oxazoles composed of carboxylic acid, amino acid, and boronic acid

A novel method for the synthesis of trisubstituted oxazoles via a one-pot oxazole synthesis/Suzuki–Miyaura coupling sequence has been developed. One-pot formation of 5-(triazinyloxy)oxazoles using carboxylic acids, amino acids and a dehydrative condensing reagent, DMT-MM, followed by Ni-catalyzed Suzuki–Miyaura coupling with boronic acids provided the corresponding 2,4,5-trisubstituted oxazoles in good yields.

Decarboxylative cross-coupling of azoyl carboxylic acids with aryl halides

Decarboxylative cross-coupling of thiazole and oxazole-5-carboxylic acids with aryl halides is reported. Under a bimetallic system of catalytic palladium and a stoichiometric silver carbonate, a variety of (hetero)arylated azoles can be prepared in excell