77888-05-2 Usage
Uses
Used in Pharmaceutical Industry:
Nitrendipine Dipropyl Ester is used as an active pharmaceutical ingredient (API) for the development of antihypertensive medications. Its role in this application is to help regulate blood pressure and alleviate the symptoms of angina by blocking calcium channels, which in turn reduces the force of heart muscle contractions and the workload on the heart.
Additionally, as an impurity in the production of Lercanidipine (L179000), Nitrendipine Dipropyl Ester may be used for quality control and assurance purposes. This ensures that the final product meets the required safety and efficacy standards, and that the presence of impurities is within acceptable limits.
Check Digit Verification of cas no
The CAS Registry Mumber 77888-05-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,8,8 and 8 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 77888-05:
(7*7)+(6*7)+(5*8)+(4*8)+(3*8)+(2*0)+(1*5)=192
192 % 10 = 2
So 77888-05-2 is a valid CAS Registry Number.
77888-05-2Relevant academic research and scientific papers
Synthesis and comparative pharmacological studies of 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylates with non-identical ester functions
Meyer,Bossert,Wehinger,Stoepel,Vater
, p. 407 - 409 (2007/10/02)
Michael-addition of 3-aminocrotonic acid ester 7 to aralkylidene acetoacetic acid esters 6 is followed by ring closure to give novel 4-aryl-1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylates 8 with non-identical ester functions. In the series of 3-nitrophenyl derivatives (8, Ar=3-nitrophenyl) the pharmacological activities (coronary vasodilation, anti-hypertensive activity) of the asymmetrically substituted derivatives are shown to be superior to those of the corresponding symmetrically substituted derivatives in many cases. One representative of this class 3-ethyl-5-methyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedica rboxylate (nitrendipine, Bay e 5009, No. 3) was selected for further development as an antihypertensive drug.
