77888-05-2

Basic information

• Product Name: Nitrendipine Dipropyl Ester
• Synonyms: Nitrendipine Dipropyl Ester;Lercanidipine Impurity 2;1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3,5-Dipropyl Ester
• CAS NO: 77888-05-2
• Molecular Formula: C21H26N2O6
• Molecular Weight: 402.44094
• Product Categories: Amines;Aromatics;Drug Analogues;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 77888-05-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Nitrendipine Dipropyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: Nitrendipine Dipropyl Ester(77888-05-2)
• EPA Substance Registry System: Nitrendipine Dipropyl Ester(77888-05-2)

Safety Data

• Hazardous Substances Data: 77888-05-2(Hazardous Substances Data)

Usage

Uses

Nitrendipine Dipropyl Ester is an analogue of the antihypertensive drug Nitrendipine (N490150). Also, Nitrendipine Dipropyl Ester is an impurity of antihypertensive Lercanidipine (L179000). Lercanidipine impurity B.

Upstream product

• 99-61-6 3-nitro-benzaldehyde 
• 1779-60-8 n-propyl acetoacetate 
• 53055-18-8 3-Aminocrotonsaeure-propylester 
• 77888-04-1 2-(3-Nitrobenzyliden)acetessigsaeure-propylester 

Relevant articles and documents

Synthesis and comparative pharmacological studies of 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylates with non-identical ester functions

Michael-addition of 3-aminocrotonic acid ester 7 to aralkylidene acetoacetic acid esters 6 is followed by ring closure to give novel 4-aryl-1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylates 8 with non-identical ester functions. In the series of 3-nitrophenyl derivatives (8, Ar=3-nitrophenyl) the pharmacological activities (coronary vasodilation, anti-hypertensive activity) of the asymmetrically substituted derivatives are shown to be superior to those of the corresponding symmetrically substituted derivatives in many cases. One representative of this class 3-ethyl-5-methyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedica rboxylate (nitrendipine, Bay e 5009, No. 3) was selected for further development as an antihypertensive drug.