77889-25-9Relevant academic research and scientific papers
Dihydroimidazoles in Synthesis: C-Alkylation of 1-Benzyl-2-(α-lithioalkyl)-4,5-dihydroimidazoles and a Synthesis of Alkanoic Acids
Anderson, Michael W.,Jones, Raymond C. F.,Saunders, John
, p. 205 - 210 (2007/10/02)
1-Benzyl-2-alkyl-4,5-dihydroimidazoles have been (laterally) metallated and C-alkylated by reaction with alkyl halides and an epoxide; intramolecular C-alkylation has led to a tetrahydro-5H-pyrroloimidazole.Hydrolysis of the 4,5-dihydroimidazoles to produce alkanoic acids completes a homologation sequence.
Nucleophilic Addition to 4,5-Dihydroimidazoles: A Ketone Synthesis via Tetrahydrofolate Coenzyme Models
Anderson, Michael W.,Jones, Raymond C.F.
, p. 1995 - 1998 (2007/10/02)
1-Benzyl-2-alkyl-3-methyl-4,5-dihydroimidazolium salts with Grignard reagents give addition products that are hydrolysed to ketones; 4,5-dihydroimidazoles and 4,5-dihydroimidazolium salts with hydride reagents afford N-alkylated ethane-1,2-diamines.
