77894-47-4

Basic information

• Product Name: 4-Hydroxy-2-(4-methoxy-phenyl)-3-phenyl-3,4-dihydro-2H-isoquinolin-1-one
• CAS NO: 77894-47-4
• Molecular Weight: 345.398
• Mol File: 77894-47-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-Hydroxy-2-(4-methoxy-phenyl)-3-phenyl-3,4-dihydro-2H-isoquinolin-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydroxy-2-(4-methoxy-phenyl)-3-phenyl-3,4-dihydro-2H-isoquinolin-1-one(77894-47-4)
• EPA Substance Registry System: 4-Hydroxy-2-(4-methoxy-phenyl)-3-phenyl-3,4-dihydro-2H-isoquinolin-1-one(77894-47-4)

Safety Data

• Hazardous Substances Data: 77894-47-4(Hazardous Substances Data)

Upstream product

• 87-41-2 2-benzofuran-1(3H)-one 
• 783-08-4 [4-(benzylideneamino)phenyl]methanol 

Downstream Products

• 77894-66-7 2-(4-methoxyphenyl)-4-phenylisoquinolin-1(2H)-one 
• 77894-53-2 Acetic acid (3R,4S)-2-(4-methoxy-phenyl)-1-oxo-3-phenyl-1,2,3,4-tetrahydro-isoquinolin-4-yl ester 
• 77894-53-2 Acetic acid (3R,4R)-2-(4-methoxy-phenyl)-1-oxo-3-phenyl-1,2,3,4-tetrahydro-isoquinolin-4-yl ester 

Relevant articles and documents

A New Route to Diarylisoquinolones

The lithium salts derived from position 3 of phthalides react with Schiff's bases to form a mixture of cis- and trans-2,3-disubstituted 4-hydroxy-3,4-dihydro-1(2H)-isoquinolones, the former isomer predominating.Acid-catalysed dehydration of the alcohols gives 2,4-disubstituted 1(2H)-isoquinolones, as a result of aryl group migration, whilst the cis-isomers, with methanesulphonyl chloride-pyridine as dehydrating agent, produce the 2,3-disubstituted 1(2H)-isoquinolones.