77894-53-2Relevant academic research and scientific papers
A New Route to Diarylisoquinolones
Dodsworth, David J.,Pia-Calcagno, Maria,Ehrmann, E. Ursula,Quesada, Andres M.,Nunez S., Oswaldo,Sammes, Peter G.
, p. 1453 - 1458 (2007/10/02)
The lithium salts derived from position 3 of phthalides react with Schiff's bases to form a mixture of cis- and trans-2,3-disubstituted 4-hydroxy-3,4-dihydro-1(2H)-isoquinolones, the former isomer predominating.Acid-catalysed dehydration of the alcohols gives 2,4-disubstituted 1(2H)-isoquinolones, as a result of aryl group migration, whilst the cis-isomers, with methanesulphonyl chloride-pyridine as dehydrating agent, produce the 2,3-disubstituted 1(2H)-isoquinolones.
A ONE-STEP ROUTE TO 4-HYDROXY-2,3-DIARYL-3,4-DIHYDRO-1(2H)-ISOQUINOLONES
Dodsworth, David J.,Caliagno, Maria-Pia,Ehrmann, Ursula E.
, p. 5075 - 5078 (2007/10/02)
A new procedure for the synthesis of 2,3-diaryl-3,4-dihydro-4-hydroxy-1(2H)-isoquinolones is described in which the cis-isomer predominates.Dehydration leads to 2,4-diarylisocarbostyrils.
