77916-92-8

Upstream product

• 120-21-8 4-Diethylaminobenzaldehyde 
• 102812-65-7 N₁,N₂-bis(4-diethylaminobenzylidene)ethane-1,2-diamine 

Downstream Products

• 1231736-69-8 1,3-bis(4-diethylaminobenzyl)imidazolidinium chloride 

Relevant academic research and scientific papers

Synthesis and biological evaluation of novel substituted-imidazolidine derivatives

A series of newer substituted-imidazolidine derivatives 3a-k were synthesized and assayed in vivo to investigate their anti-inflammatory, analgesic and antiulcer activity. The results of biological evaluation revealed that the three compounds, 4-[1,3-bis(4-hydroxy-3-methoxybenzyl)-2- imidazolidinyl]phenyldiethylamine (3g), 4-[1,3-bis(3-Ethoxy-4-hydroxybenzyl)-2- imidazolidinyl] phenyldiethylamine (3h) and 4-(1,3-bis(benzo[d][1,3]dioxol-5- ylmethyl)-4-methylimidazolidin-2-yl)-N,N-diethylbenzenamine (3j) were good in their anti-inflammatory and analgesic actions. Additionally these derivatives showed superior GI safety profile as compared to that of the standard drug in terms of low severity index. The results are statistically treated for its significance.

Preparation of a series of Ru(ii) complexes with N-heterocyclic carbene ligands for the catalytic transfer hydrogenation of aromatic ketones

The reaction of [RuCl2(p-cymene]2 with Ag-N-heterocyclic carbene (NHC) complexes yields a series of [(p-cymene)Ru(NHC)] complexes (2a-f). All synthesised compounds were characterized by elemental analysis, NMR spectroscopy and the mo

Synthesis of novel tetrahydroimidazole derivatives and studies for their biological properties

Ethylenediamine was reacted with suitable aromatic aldehydes in order to prepare their respective diSchiff bases. These compounds were then reduced to give the corresponding tetrahydrodiSchiff bases, which were low melting in nature. Finally, these derivatives were condensed with different aromatic aldehydes to give the desired tetrahydroimidazoles. The structures of all these compounds were established on the basis of spectral data. These novel tetrahydroimidazoles showed promising anti-inflammatory and analgesic activity. The compounds were also screened for their anti-bacterial property against Staphylococcus aureus and Escherichia coli.

1-(4-Aminobenzyl)-2,3-dioxopiperazine derivatives, acid addition salts thereof and process for producing same

A 1-(4-aminobenzyl)-2,3-dioxopiperazine derivative represented by the formula: STR1 and an acid addition salt thereof have excellent carcinostatic activity but a low toxicity. Therefore, said compounds are useful as medicines and also as intermediates.