77918-89-9

Upstream product

• 63-91-2 L-phenylalanine 

Downstream Products

• 127604-59-5 2-amino-3-phenyl-propionic acid 3-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-propyl ester 
• 127604-63-1 2-amino-3-phenyl-propionic acid 4-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-butyl ester 
• 792909-72-9 2-amino-3-phenyl-propionic acid 5-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pentyl ester 
• 127604-72-2 (Z)-3-{(S)-1-[3-(5-Fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-propoxycarbonyl]-2-phenyl-ethylamino}-but-2-enoic acid ethyl ester 
• 127604-80-2 (Z)-3-{(S)-1-[4-(5-Fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-butoxycarbonyl]-2-phenyl-ethylamino}-but-2-enoic acid ethyl ester 

Relevant academic research and scientific papers

Natural amino acid salt catalyzed aldol reactions of isatins with ketones: highly enantioselective construction of 3-alkyl-3-hydroxyindolin-2-ones

Abstract The asymmetric synthesis of 3-alkyl-3-hydroxyindolin-2-ones via direct aldol reaction of isatin with ketones catalyzed by natural amino acid salts is described, in which the phenylalanine lithium salt was found to be the best catalyst. This strategy was then applied to a variety of isatin and ketone substrates and the corresponding aldol products were obtained in excellent yields (up to 97%) with good to excellent enantioselectivities (up to 90%).