N',N''-diacetylspermine is a diacetylated derivative of spermine, an endogenous polyamine synthesized from spermidine. It exhibits lower Km and higher Vmax values than spermine, making it a more efficient substrate for polyamine oxidase than the non-acetylated polyamine. Spermine is essential for eukaryotic cell growth, protein synthesis, and the modulation of calcium-dependent immune processes. The upregulation of N',N''-diacetylspermine has been associated with the incidence of cancer, which makes this natural polyamine a potential biomarker for cancer detection.
77928-71-3
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Basic information
- Product Name: N',N''-diacetylspermine
- Synonyms: N',N''-diacetylspermine;DIACETYLSPERMINE;N,N'-[1,4-butanediylbis(imino-3,1-propanediyl)]bis-acetamide, dihydrochloride;N1,N12-Diacetylspermine hydrochloride
- CAS NO:77928-71-3
- Molecular Formula: C14H30 N4 O2 . 2 Cl H
- Molecular Weight: 322.88
- EINECS: N/A
- Product Categories: N/A
- Mol File: 77928-71-3.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
- Solubility: DMSO (Slightly, Heated, Sonicated), Methanol (Slightly), Water (Slightly)
- Stability: Hygroscopic
- CAS DataBase Reference: N',N''-diacetylspermine(CAS DataBase Reference)
- NIST Chemistry Reference: N',N''-diacetylspermine(77928-71-3)
- EPA Substance Registry System: N',N''-diacetylspermine(77928-71-3)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 77928-71-3(Hazardous Substances Data)
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77928-71-3 Usage
Uses
Used in Cancer Detection:N',N''-diacetylspermine is used as a biomarker for the early detection of cancer, particularly breast and colorectal cancers. Its upregulation in these types of cancer makes it a valuable tool for identifying the presence of tumors and monitoring the progression of the disease.
Used in Pharmaceutical Research:
N',N''-diacetylspermine is used as a research compound in the development of new drugs targeting cancer cells. Its role in the upregulation of cancer incidence and its interaction with polyamine oxidase make it a promising candidate for the design of novel therapeutic agents.
Used in Diagnostics:
N',N''-diacetylspermine is used in the development of diagnostic tests for cancer, specifically breast and colorectal cancers. The detection of elevated levels of this biomarker in patients can aid in the confirmation of a cancer diagnosis and guide treatment decisions.
Used in Anticancer Applications:
While not explicitly mentioned in the provided materials, given the association of N',N''-diacetylspermine with cancer incidence, it could potentially be used as an anticancer agent or in combination with conventional chemotherapeutic drugs to enhance their efficacy and overcome resistance in cancer treatment.
Used in Drug Delivery Systems:
Similar to gallotannin, N',N''-diacetylspermine could be employed in the development of novel drug delivery systems to improve its delivery, bioavailability, and therapeutic outcomes in cancer treatment. Organic and metallic nanoparticles could be used as carriers for N',N''-diacetylspermine, targeting cancer cells more effectively.
Check Digit Verification of cas no
The CAS Registry Mumber 77928-71-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,9,2 and 8 respectively; the second part has 2 digits, 7 and 1 respectively.Calculate Digit Verification of CAS Registry Number 77928-71:
(7*7)+(6*7)+(5*9)+(4*2)+(3*8)+(2*7)+(1*1)=183
183 % 10 = 3
So 77928-71-3 is a valid CAS Registry Number.
77928-71-3Upstream product
77928-71-3Downstream Products
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N',N''-diacetylspermine
