779293-65-1

Upstream product

• 136382-02-0 N-(4-(2-bromoacetyl)-3,5-dimethylphenyl)acetamide 
• 17356-08-0 thiourea 
• 100923-73-7 N-(4-acetyl-3,5-dimethylphenyl)acetamide 
• 2050-45-5 N-acetyl-3,5-dimethylaniline 
• 108-69-0 3,5-dimethylaminoaniline 

Downstream Products

• 1334920-31-8 N-(4-(4-chloro-2,6-dimethylphenyl)thiazol-2-yl)isonicotinamide 
• 1439935-97-3 N-(4-(4-hydroxy-2,6-dimethylphenyl)thiazol-2-yl)isonicotinamide 
• 1587705-63-2 N-(4-(2,6-dimethyl-4-(piperidin-1-yl)phenyl)thiazol-2-yl)isonicotinamide 
• 1334920-26-1 N-[4-(4-ethoxy-2,6-dimethylphenyl)thiazol-2-yl]pyridine-4-carboxamide 

Relevant academic research and scientific papers

SMALL MOLECULE MODIFIERS OF THE HEC1-NEK2 INTERACTION IN G2/M

Certain embodiments of the present invention provide selected compounds having a molecular structure according to Formula 1: In Formula 1, Z is —CO—, —SO—, or —SO2—; Ar is phenyl, heteroaryl, or heterocycloalkyl; Het is heteroaryl; R is R″, X,

IMPROVED MODULATORS OF HEC1 ACTIVITY AND METHODS THEREFOR

Compounds, compositions, and methods for modulation of Hec1/Nek2 interaction are provided. Such compounds disrupt Nek2/Hec1 binding and may be useful as chemotherapeutic agents for neoplastic diseases

Modulators Of HEC1 Activity And Methods Therefor

Compounds, compositions, and methods for modulation of Hec1/Nek2 interaction are provided. Especially preferred compounds disrupt Nek2/Hec1 binding and are therefore useful as chemotherapeutic agent for neoplastic diseases.