779323-03-4

Basic information

• Product Name: Pyrrolo[1,2-b]pyridazine-3-carbonitrile, 6-amino-5-methyl-4-[(4-phenoxyphenyl)amino]-
• CAS NO: 779323-03-4
• Molecular Formula: C21H17N5O
• Molecular Weight: 355.399
• Mol File: 779323-03-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Pyrrolo[1,2-b]pyridazine-3-carbonitrile, 6-amino-5-methyl-4-[(4-phenoxyphenyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrolo[1,2-b]pyridazine-3-carbonitrile, 6-amino-5-methyl-4-[(4-phenoxyphenyl)amino]-(779323-03-4)
• EPA Substance Registry System: Pyrrolo[1,2-b]pyridazine-3-carbonitrile, 6-amino-5-methyl-4-[(4-phenoxyphenyl)amino]-(779323-03-4)

Safety Data

• Hazardous Substances Data: 779323-03-4(Hazardous Substances Data)

Upstream product

• 427878-69-1 1-amino-3-methyl-1H-pyrrole-2,4-dicarboxylic acid diethyl ester 
• 5448-16-8 3-methyl-1H-pyrrole-2,4-dicarboxylic acid diethyl ester 
• 612083-24-6 3-Cyano-5-methyl-4-[(4-phenoxyphenyl)amino]pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester 
• 612082-29-8 3-Cyano-5-methyl-4-[(4-phenoxyphenyl)amino]pyrrolo[1,2-b]pyridazine-6-carboxylic acid 
• 612085-98-0 3-Cyano-1,4-dihydro-5-methyl-4-oxopyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester 
• 612085-99-1 4-Chloro-3-cyano-5-methylpyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester 
• 612086-01-8 [3-Cyano-5-methyl-4-[(4-phenoxyphenyl)amino]pyrrolo[1,2-b]pyridazin-6-yl]carbamic acid, phenylmethyl ester 

Relevant articles and documents

Pyrrolopyridazine MEK inhibitors

The synthesis and SAR of a series of pyrrolopyridazine MEK inhibitors are reported. Optimal activity was achieved by incorporation of a 4-phenoxyaniline substituent at C4 and an acylated amine at C6.