427878-69-1

Basic information

• Product Name: DIETHYL 1-AMINO-3-METHYL-1H-PYRROLE-2,4-DICARBOXYLATE
• Synonyms: DIETHYL 1-AMINO-3-METHYL-1H-PYRROLE-2,4-DICARBOXYLATE;1-AMino-3-Methyl-1H-pyrrole-2,4-dicarboxylic acid diethyl ester
• CAS NO: 427878-69-1
• Molecular Formula: C₁₁H₁₆N₂O₄
• Molecular Weight: 240.26
• Mol File: 427878-69-1.mol
• Article Data: 17

Chemical Properties

• Melting Point: 57.0-59.0 °C
• Boiling Point: 367.2±52.0 °C(Predicted)
• Appearance: /
• Density: 1.24±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -4.43±0.70(Predicted)
• CAS DataBase Reference: DIETHYL 1-AMINO-3-METHYL-1H-PYRROLE-2,4-DICARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: DIETHYL 1-AMINO-3-METHYL-1H-PYRROLE-2,4-DICARBOXYLATE(427878-69-1)
• EPA Substance Registry System: DIETHYL 1-AMINO-3-METHYL-1H-PYRROLE-2,4-DICARBOXYLATE(427878-69-1)

Safety Data

• Hazardous Substances Data: 427878-69-1(Hazardous Substances Data)

Usage

General Description

DIETHYL 1-AMINO-3-METHYL-1H-PYRROLE-2,4-DICARBOXYLATE is a chemical compound with a complex molecular structure that includes two ethyl groups, an amino group, a methyl group, and a pyrrole ring with two carboxylate groups attached at positions 2 and 4. DIETHYL 1-AMINO-3-METHYL-1H-PYRROLE-2,4-DICARBOXYLATE is a pyrrole derivative and may be used as a building block in the synthesis of various organic compounds, including pharmaceuticals and agrochemicals. It may also have potential applications in the field of materials science due to its unique structure and properties. Additionally, it is important to handle this compound with care and adhere to proper safety protocols when working with it in a laboratory or industrial setting.

Upstream product

• 5448-16-8 3-methyl-1H-pyrrole-2,4-dicarboxylic acid diethyl ester 
• 35657-36-4 O-(4-nitrobenzoyl) hydroxylamine 
• 17508-17-7 O-(2,4-dinitrophenyl)hydroxylamine 
• 141-97-9 ethyl acetoacetate 
• 134653-70-6 ethyl 2-[(dimethylamino)methylene]-3-oxobutanoate 
• 875572-14-8 C₁₉H₁₈N₂O₆ 
• 875572-10-4 C₂₃H₂₄N₂O₄ 
• 875572-09-1 C₂₅H₂₈N₂O₄ 
• 2999-46-4 Ethyl isocyanoacetate 

Downstream Products

• 427878-70-4 ethyl 5-methyl-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylate 
• 427878-70-4 ethyl 4-hydroxy-5-methylpyrrolo[2,1-f ][1,2,4]-triazine-6-carboxylate 
• 427878-70-4 C₁₀H₁₁N₃O₃ 
• 310435-15-5 C₈H₇N₃O₃ 
• 529508-54-1 C₇H₇N₃O 
• 529508-56-3 4-chloro-5-methylpyrrolo[2,1-f][1,2,4]triazine 
• 529508-57-4 5-(bromomethyl)-4-chloropyrrolo[2,1-f][1,2,4]triazine 
• 1400934-27-1 C₁₆H₁₄BrN₃O₃ 
• 1400934-31-7 C₁₇H₁₇N₃O₄ 
• 1400934-02-2 diethyl 1-(4-nitrobenzamido)-3-methyl-1H-pyrrole-2,4-dicarboxylate 
• 427877-66-5 ethyl 4-((5-(methoxycarbamoyl)-2-methylphenyl)-amino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate 
• 1005196-62-2 4-((5-(methoxycarbamoyl)-2-methylphenyl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid 
• 427878-02-2 N-ethyl 4-((5-(methoxycarbamoyl)-2-methylphenyl)-amino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide 
• 1400934-06-6 diethyl 1-(3-chlorobenzamido)-3-methyl-1H-pyrrole-2,4-dicarboxylate 

Relevant articles and documents

An efficient electrophilic N-amination utilizing in situ generated chloramine under phase transfer conditions

An efficient, one-pot, phase transfer N-amination technology was developed. The protocol utilizes chloramine, an inexpensive and safe electrophilic aminating agent potentially viable for commercial manufacturing.

TYROSINE KINASE INHIBITOR AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

The present invention relates to a tyrosine kinase inhibitor and a pharmaceutical composition comprising same. The tyrosine kinase inhibitor of the present invention has the structures as shown in the following formula (I) or (II):

Development of a practical synthesis of a functionalized pyrrolo[2,1-f][1,2,4]triazine nucleus

Functionalized pyrrolotriazine 1b is a key heterocyclic building block in the synthesis of BMS-690514, a potent anticancer agent. Described herein are our development activities that led to the efficient preparation of 1b on a large scale. The key transformations include a selective C-alkylation of an oxalacetate salt with a hydrazonyl bromide to form a 2-hydrazonoethyl-3- oxosuccinate, followed by cyclodehydration to an aminopyrrole. Subsequent deprotection and condensation with formamidine afforded the pyrrolotriazine scaffold. Further elaboration of this core provided the desired pyrrolotriazinyl amine.