779331-12-3

Usage

Chemical class

boronic acids

Common use

reagent in organic synthesis, specifically in the Suzuki-Miyaura cross-coupling reaction for carbon-carbon bond formation

Structure

contains a boron atom bonded to two oxygen atoms and an aryl group

Functionalities

unique combination of aromatic and boronic functionalities, valuable for pharmaceuticals, agrochemicals, and materials science development

Trifluoromethyl group

enhances lipophilicity and can influence biological activity and pharmacokinetic properties.

Upstream product

• 612833-41-7 [2-(phenylmethoxy)-5-(trifluoromethyl)phenyl]-boronic acid 
• 76-09-5 2,3-dimethyl-2,3-butane diol 
• 200956-32-7 1-(benzyloxy)-2-bromo-4-(trifluoromethyl)benzene 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 33400-80-5 2-(pyridin-2-yl)-4-(trifluoromethyl)phenol 

Relevant academic research and scientific papers

SULFONAMIDE COMPOUNDS AS VOLTAGE GATED SODIUM CHANNEL MODULATORS

The present invention relates to the compound of Formula (I) wherein the substituents are as described herein, and their use in a medicine for the treatment of diseases, disorders associated with the inhibition of Voltage-gated sodium channels (VGSC) particularly NaV1.7. It further relates to the compounds herein and their pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof useful in treating diseases, disorders, syndromes and/or conditions associated with the inhibition of Voltage-gated sodium channels (VGSC) particularly NaV1.7. The invention also relates to process for the preparation of the compounds of the invention.

NOVEL COMPOUNDS

Novel Compounds The invention relates to substituted acids as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.

NOVEL COMPOUNDS

The invention relates to substituted phenoxyacetic acids (I) as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation