779358-26-8

Upstream product

• 779358-25-7 Trifluoro-methanesulfonic acid 1-((R)-4-methyl-cyclohex-3-enyl)-vinyl ester 
• 58753-02-9 4-benzoylcyclohexanone 
• 4680-24-4 cis-(R)-limonene oxide 
• 6090-09-1 methyl-[(1R)-4-methylcyclohex-3-enyl]ketone 

Downstream Products

• 779358-27-9 (1R,5R,8R)-8-Methyl-4-phenyl-4-phenylsulfanylmethyl-2,3-dioxa-bicyclo[3.3.1]non-8-yl-hydroperoxide 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 779358-34-8 Acetic acid (1R,4S,5R,8R)-4-formyl-8-methyl-4-phenyl-2,3-dioxa-bicyclo[3.3.1]non-8-yl ester 
• 779358-28-0 (1R,4S,5R,8R)-8-Methyl-4-phenyl-4-phenylsulfanylmethyl-2,3-dioxa-bicyclo[3.3.1]nonan-8-ol 
• 779358-35-9 Acetic acid (1R,4R,5R,8R)-8-methyl-4-phenyl-4-((Z)-styryl)-2,3-dioxa-bicyclo[3.3.1]non-8-yl ester 
• 779358-32-6 Acetic acid (1R,4S,5R,8R)-8-methyl-4-phenyl-4-phenylsulfanylmethyl-2,3-dioxa-bicyclo[3.3.1]non-8-yl ester 
• 779358-33-7 Acetic acid (1R,4S,5R,8R)-4-benzenesulfinylmethyl-8-methyl-4-phenyl-2,3-dioxa-bicyclo[3.3.1]non-8-yl ester 
• 779358-31-5 Trimethyl-((1R,4S,5R,8R)-8-methyl-4-phenyl-4-phenylsulfanylmethyl-2,3-dioxa-bicyclo[3.3.1]non-8-yloxy)-silane 

Relevant academic research and scientific papers

Cobalt-Catalyzed Desymmetric Isomerization of Exocyclic Olefins

Chiral cyclic olefins, 1-methylcyclohexenes, are versatile building blocks for the synthesis of pharmaceuticals and natural products. Despite the prevalence of these structural motifs, the development of efficient synthetic methods remains an unmet challenge. Herein we report a novel desymmetric isomerization of exocyclic olefins using a series of newly designed chiral cobalt catalysts, which enables a straightforward construction of chiral 1-methylcyclohexenes with diversified functionalities. The synthetic utility of this methodology is highlighted by a concise and enantioselective synthesis of a natural product, β-bisabolene. The versatility of the reaction products is further demonstrated by multifarious derivatizations.

Design and synthesis of endoperoxide antimalarial prodrug models

A masked combination chemotherapy which relies on the embedding of a number of active components, in a latent form, within a single endoperoxidic chemical entity is the aim of the research presented. The approach is illustrated by means of purposely designed bicyclic endoperoxide prodrug prototypes 1 and subsequently validated through the study of model compounds 2 (Ar= Ph, p-FC 6H4, p-ClC6H4.