77942-38-2Relevant academic research and scientific papers
Reaction of Pyrimidin-2(1H)-ones and -thiones with Organometallic Compounds. Regioselective Preparation of Dihydropyrimidin-2(1H)-ones and -thiones
Kashima, Choji,Katoh, Akira,Yokota, Yuko,Omote, Yoshimori
, p. 489 - 492 (1981)
4,6-Dimethyl-1-phenylpyrimidin-2(1H)-one (1) reacted with methylmagnesium iodide to afford 4,6,6-trimethyl-1-phenyl-3,6-dihydropyrimidin-2(1H)-one (8a) selectively; compound (1) reacted with methyl-lithium to give mainly 4,4,6-trimethyl-1-phenyl-3,4-dihydropyrimidin-2(1H)-one (8b).The reactions of various pyrimidin-2(1H)-ones and -thiones with organometallic compounds, and the influence of bulkiness of alkyl groups upon the product ratio, are also discussed.
