Journal of the Chemical Society. Perkin transactions I p. 489 - 492 (1981)
Update date:2022-08-03
Topics:
Kashima, Choji
Katoh, Akira
Yokota, Yuko
Omote, Yoshimori
4,6-Dimethyl-1-phenylpyrimidin-2(1H)-one (1) reacted with methylmagnesium iodide to afford 4,6,6-trimethyl-1-phenyl-3,6-dihydropyrimidin-2(1H)-one (8a) selectively; compound (1) reacted with methyl-lithium to give mainly 4,4,6-trimethyl-1-phenyl-3,4-dihydropyrimidin-2(1H)-one (8b).The reactions of various pyrimidin-2(1H)-ones and -thiones with organometallic compounds, and the influence of bulkiness of alkyl groups upon the product ratio, are also discussed.
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