7795-51-9

Basic information

• Product Name: (S)-2-(1H-indol-3-yl)-1-Methyl-ethylaMine
• Synonyms: (S)-2-(1H-indol-3-yl)-1-Methyl-ethylaMine;(R)-1-(1H-indol-3-yl)propan-2-amine;(S)-alpha-Methyltryptamine;(2S)-1-(1H-indol-3-yl)propan-2-amine
• CAS NO: 7795-51-9
• Molecular Formula: C₁₁H₁₄N₂
• Molecular Weight: 174.24226
• EINECS: -0
• Mol File: 7795-51-9.mol
• Article Data: 9

Chemical Properties

• Melting Point: 125-126°
• Boiling Point: 344.5±17.0 °C(Predicted)
• Appearance: /
• Density: 1.122±0.06 g/cm3(Predicted)
• PKA: 17.22±0.30(Predicted)
• CAS DataBase Reference: (S)-2-(1H-indol-3-yl)-1-Methyl-ethylaMine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-(1H-indol-3-yl)-1-Methyl-ethylaMine(7795-51-9)
• EPA Substance Registry System: (S)-2-(1H-indol-3-yl)-1-Methyl-ethylaMine(7795-51-9)

Safety Data

• Hazardous Substances Data: 7795-51-9(Hazardous Substances Data)

Upstream product

• 64252-02-4 3-(β-nitro-β-methylvinyl)indole 
• 299-26-3 1-(1H-indol-3-yl)propan-2-amine 
• 3938-96-3 ethyl 2-methoxyacetate 
• 487-89-8 Indole-3-carboxaldehyde 
• 61535-48-6 C₂₆H₂₆N₂O₅S 
• 108-20-3 di-isopropyl ether 
• 4771-72-6 α-methyl-β-(3-indolyl)-1-nitroethane 
• 1201-26-9 3-(1H-indolyl)acetone 
• 113997-59-4 (S,S)-N-α-phenetyl-1-indol-3-yl-2-aminopropane 
• 113997-60-7 (S)-1-(1H-indol-3-yl)-N-((R)-1-phenylethyl)propan-2-amine 
• 371-27-7 2,2,2-trifluoroethylbutyrate 

Downstream Products

• 1193314-21-4 (1R,3S)-5'-chloro-3-methyl-2,3,4,9-tetrahydrospiro[β-carboline-1,3'-indol]-2'(1'H)-one 

Relevant articles and documents

COMPOUNDS AND METHOD OF USE

This present disclosure relates to compounds with ferroptosis inducing activity, a method of treating a subject with cancer with the compounds, and combination treatments with a second therapeutic agent.

Straightforward preparation of biologically active 1-aryl- and 1-heteroarylpropan-2-amines in enantioenriched form

Because of the importance of developing stereoselective syntheses for single enantiomers, a selected panel of racemic biologically active 1-aryl- and 1-heteroarylpropan-2-amines has been prepared, followed by a study of their behavior in enzymatic kinetic resolution (KR) processes. For this purpose, lipase B from Candida antarctica (CAL-B) proved to be an ideal biocatalyst allowing the preparation of the corresponding enantioenriched (R)-amides and (S)-amines by aminolysis reactions. Likewise, dynamic kinetic resolutions (DKR) have been successfully achieved combining the use of CAL-B and Shvo's catalyst. This research constitutes the first example of a lipase-catalyzed DKR process of β-substituted isopropylamines.

ORGANIC COMPOUNDS

The invention relates to organic compounds which have interesting pharmaceutical properties. In particular, the compounds are useful in the treatment and/or prevention of infections such as those caused by Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, Plasmodium ovale, Trypanosoma cruzi and parasites of the Leishmania genus such as, for example, Leishmania donovani. The invention also relates to pharmaceutical compositions containing the compounds, as well as processes for their preparation.