1201-26-9

Basic information

• Product Name: Indole-3-acetone
• Synonyms: 3-INDOLYLACETONE;1-(1H-INDOL-3-YL)PROPAN-2-ONE;INDOLE-3-ACETONE;1-(1H-indol-3-yl)acetone;2-Propanone, 1-(1H-indol-3-yl);3-(2-Oxopropyl)indole;3-Acetonylindole;Indol-3-yl-2-propanone
• CAS NO: 1201-26-9
• Molecular Formula: C₁₁H₁₁NO
• Molecular Weight: 173.21
• EINECS: 214-855-4
• Product Categories: Indoles and derivatives;Aromatic Ketones (substituted);Indole;Indoles
• Mol File: 1201-26-9.mol
• Article Data: 7

Chemical Properties

• Melting Point: 116°C
• Boiling Point: 303.86°C (rough estimate)
• Flash Point: 168.4 °C
• Appearance: tan/
• Density: 1.0898 (rough estimate)
• Vapor Pressure: 7.93E-05mmHg at 25°C
• Refractive Index: 1.4950 (estimate)
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: Indole-3-acetone(CAS DataBase Reference)
• NIST Chemistry Reference: Indole-3-acetone(1201-26-9)
• EPA Substance Registry System: Indole-3-acetone(1201-26-9)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 1201-26-9(Hazardous Substances Data)

Usage

Chemical Properties

mp 115-117°C

Uses

3-Indolylacetone is an indole derivative that may act as a benzodiazepine receptor inhibitor.

InChI:InChI=1/C11H11NO/c1-8(13)6-9-7-12-11-5-3-2-4-10(9)11/h2-5,7,12H,6H2,1H3

Upstream product

• 120-72-9 indole 
• 2684-62-0 diazoacetone 
• 110-82-7 cyclohexane 
• 83-34-1 3-Methylindole 
• 75-36-5 acetyl chloride 
• 87-51-4 indole-3-acetic acid 
• 75-16-1 methylmagnesium bromide 
• 132922-37-3 2-(1H-indol-3-yl)-N-methoxy-N-methyl-acetamide 
• 676-58-4 methylmagnesium chloride 
• 4771-72-6 α-methyl-β-(3-indolyl)-1-nitroethane 
• 105903-08-0 (1-acetyl-indol-3-yl)-acetone 
• 84584-89-4 3-(2-nitro-propenyl)-1H-indole 

Downstream Products

• 3364-35-0 3-<2-Hydroxy-propyl>-indol 
• 22314-94-9 3-Methylharman 
• 299-26-3 1-(1H-indol-3-yl)propan-2-amine 
• 113997-59-4 (S,S)-N-α-phenetyl-1-indol-3-yl-2-aminopropane 
• 113997-58-3 (R)-1-(1H-indol-3-yl)-N-((R)-1-phenylethyl)propan-2-amine 
• 221282-92-4 2-Phenyl-3-[2-(piperidin-1-yl)prop-1-yl]-1H-indole 

Relevant articles and documents

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Versatile synthesis of functionalized β- And γ-carbolines: Via Pd-catalyzed C-H addition to nitriles/cyclization sequences

The first example of versatile synthesis of functionalized β-carbolines and γ-carbolines via redox-free Pd-catalyzed C-H addition of indole to nitrile/cyclization sequences is reported. A wide range of functionalized β-carbolines and γ-carbolines can be prepared from readily accessible indoles and nitriles in good to excellent yields under the optimal conditions.

Fe-HCl: An efficient reagent for deprotection of oximes as well as selective oxidative hydrolysis of nitroalkenes and nitroalkanes to ketones

Fe-HCl mixture was found to selectively perform oxidative hydrolysis of the nitroalkenes 1a-j and nitroalkanes 2a-j to the ketones 3a-j. Also, the reagent was observed to deprotect the oximes 7a-j to carbonyl compounds 8a-j in excellent yields.