77955-04-5

Upstream product

• 67-64-1 acetone 
• 873-76-7 para-Chlorobenzyl alcohol 
• 77955-21-6 1-(4-Carbomethoxyphenyl)propan-2-one ethylene ketal 
• 87736-74-1 4-(tert-butyldimethylsiloxymethyl)bromobenzene 

Downstream Products

• 1428451-10-8 N-[2-(4-acetoxymethylphenyl)acetyl] thiourea 
• 1428451-05-1 N-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)-2-(4-(hydroxymethyl)phenyl)acetamide 
• 61165-81-9 p-(acetoxymethyl)phenylacetic acid 
• 848574-04-9 1,1,1-trifluoro-3-[4-(2-oxo-propyl)-phenyl]-propan-2-one 

Relevant academic research and scientific papers

Palladium-catalyzed mono-α-arylation of acetone with aryl halides and tosylates

We report the first example of selective Pd-catalyzed mono-α- arylation of acetone employing aryl chlorides, bromides, iodides, and tosylates. The use of appropriately designed P,N-ligands proved to be the key to controlling the reactivity and selectivity. The reaction affords good yields with substrates containing a range of functional groups at modest Pd loadings using Cs2CO3 as the base and employing acetone as both a reagent and the solvent.(Figure Presented)

Chemoselective reduction of ketones: Trifluoromethylketones versus methylketones

Treatment of an equimolar mixture of trifluoromethylketones (TFMKs) and methylketones (MKs) with Et2Zn resulted in selective reduction of the TFMKs in good yield. In contrast, treatment of an equimolar mixture of TFMKs and MKs with NaBH4 in the presence of CeCl3 in EtOH/H 2O (10:1) at -10°C reduced only the MKs.

Secondary amines, their preparation and use in pharmaceutical compositions

Compounds having the formula: STR1 where R1, R2, R3, R4, R5, Y and X are as defined hereinbelow, are useful for the reduction of abnormally high blood glucose and lipid levels in the treatment of obesity or hyperglycaemia.