77988-87-5

Basic information

• Product Name: 1,4-Diphenyl-3,4-dihydroisoquinoline
• Synonyms: 1,4-Diphenyl-3,4-dihydroisoquinoline
• CAS NO: 77988-87-5
• Molecular Formula: C₂₁H₁₇N
• Molecular Weight: 0
• Mol File: 77988-87-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,4-Diphenyl-3,4-dihydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Diphenyl-3,4-dihydroisoquinoline(77988-87-5)
• EPA Substance Registry System: 1,4-Diphenyl-3,4-dihydroisoquinoline(77988-87-5)

Safety Data

• Hazardous Substances Data: 77988-87-5(Hazardous Substances Data)

Usage

Class

Tetrahydroisoquinolines (a subclass of isoquinoline alkaloids)

Physical state

Yellow, crystalline solid

Solubility

Insoluble in water, soluble in organic solvents

Uses

a. Organic synthesis
b. Building block for pharmaceutical compounds

Applications

a. Medicinal chemistry
b. Development of new drugs for various diseases and conditions

Upstream product

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Relevant articles and documents

Diprotonative stabilization of ring-opened carbocationic intermediates: conversion of tetrahydroisoquinoline to triarylmethanes

Superacid-promoted conversion of tetrahydroisoquinolines to triarylmethanes via tandem reactions of C-N bond scission, Friedel-Crafts alkylation, C-O bond scission, and electrophilic aromatic amidation was developed. Dication formation was important for stabilizing the ring-opened carbocationic intermediate, which is a new role for diprotonation in reaction mechanisms. This journal is

The mechanism of the Bischler-Napieralski Reaction

The Bischler-Napieralski dihydroisoquinoline synthesis was proven to occur via imidoyl chlorides and the corresponding nitrilium salt.Two-step process required much milder conditions (20 degC - 50 degC) compared to drastic classical conditions of refluxing at 100 degC - 200 degC.The Bischler-Napieralski reaction is shown to share a common intermediate with two other well-known reactions: the von Braun and the Ritter reactions