77992-46-2

Basic information

• Product Name: (5-IODO-PYRIDIN-2-YL)-HYDRAZINE
• Synonyms: (5-IODO-PYRIDIN-2-YL)-HYDRAZINE;2-hydrazinyl-5-iodoPyridine
• CAS NO: 77992-46-2
• Molecular Formula: C₅H₆IN₃
• Molecular Weight: 235.03
• Mol File: 77992-46-2.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (5-IODO-PYRIDIN-2-YL)-HYDRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: (5-IODO-PYRIDIN-2-YL)-HYDRAZINE(77992-46-2)
• EPA Substance Registry System: (5-IODO-PYRIDIN-2-YL)-HYDRAZINE(77992-46-2)

Safety Data

• Hazardous Substances Data: 77992-46-2(Hazardous Substances Data)

Usage

General Description

(5-IODO-PYRIDIN-2-YL)-HYDRAZINE is a chemical compound with the formula C5H6IN3. It consists of a pyridine ring with an attached hydrazine group and an iodine atom. (5-IODO-PYRIDIN-2-YL)-HYDRAZINE is used in organic synthesis as a reagent for the preparation of various pharmaceuticals and agrochemicals. It has also shown potential as a building block for the development of novel materials and biologically active compounds. The presence of the iodo and hydrazine groups make it a versatile molecule for the construction of diverse chemical structures and functional groups, making it an important tool for chemical research and development.

Upstream product

• 69045-79-0 2-choro-5-iodopyridine 
• 73290-22-9 2-bromo-5-iodo-pyridine 
• 20511-12-0 2-amino-5-iodopyridine 
• 504-29-0 2-aminopyridine 

Downstream Products

• 1293979-77-7 6-iodo-3,3-difluoro-2-(4-(thiophen-2-yl)benzylidene)-2,3-dihydro-[1,2,4,3]triazaborolo[4,5-a]pyridin-2-ium-3-uide 
• 1293979-87-9 6-(4-(2-amino-3-((4-methoxyphenyl)diphenylmethylthio)-propanamido)but-1-ynyl)-3,3-difluoro-2-(propan-2-ylidene)-2,3-dihydro[1,2,4,3]triazaborolo[4,5-a]pyridin-2-ium-3-uide 
• 1293385-65-5 5-iodo-2-(2-(4-(thiophen-2-yl)benzylidene)hydrazinyl)pyridine 
• 1418143-35-7 5-iodo-2-(2-(3-(trifluoromethyl)benzylidene)hydrazinyl)pyridine 

Relevant articles and documents

Synthesis of 2,3-Disubstituted 5-Iodo-1H-Pyrrolo[2,3-b]pyridines via Fischer Cyclization

A simple and convenient procedure for the preparation of some unknown 2,3-disubstituted 5-iodo-1H-pyrrolo[2,3-b]pyridines from readily available starting materials by Fischer indole cyclization in polyphosphoric acid is described. The present methodology provides an alternative synthetic approach to the synthesis of 5-iodo-7-azaindole scaffold. All synthesized compounds were characterized by IR, MS, 1H and 13C NMR, and elemental analysis.

A novel pyrazolopyridine with in vivo activity in Plasmodium berghei- and Plasmodium falciparum-infected mouse models from structure-activity relationship studies around the core of recently identified antimalarial imidazopyridazines

Toward improving pharmacokinetics, in vivo efficacy, and selectivity over hERG, structure-activity relationship studies around the central core of antimalarial imidazopyridazines were conducted. This study led to the identification of potent pyrazolopyridines, which showed good in vivo efficacy and pharmacokinetics profiles. The lead compounds also proved to be very potent in the parasite liver and gametocyte stages, which makes them of high interest.

Nitrogen bicyclic compounds as inhibitors for Scyl1 and Grk5

The present invention relates to compounds assumed to be capable of modulating the activity of the proteins ScyI1 and Grk5, thereby regulating the expression and/or release of insulin as well as to pharmaceutical compositions containing such compounds and the use thereof especially for the treatment of a metabolic disease such as diabetes, obesity and impaired adipogenesis.