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78-51-3 Usage


Tris(2-butoxyethyl) phosphate, also known as a trialkyl phosphate, is an organic flame retardant with PXR agonistic activity. It is a slightly yellow, oily liquid that is insoluble or has limited solubility in glycerol, glycols, and certain amines, but is soluble in most organic liquids. Tris(2-butoxyethyl) phosphate is combustible and has been detected and quantified in various samples, such as herring gull eggs, house dust, and urine, using liquid chromatography-electrospray ionization(+)-tandem mass spectrometry.


Used in Analytical Chemistry:
Tris(2-butoxyethyl) phosphate is used as an analytical reference standard for the quantification of the analyte in herring gull eggs, house dust, and urine samples. This application utilizes liquid chromatography techniques to accurately measure the presence and concentration of the compound in these samples.
Used in Plastics and Elastomers Industry:
Tris(2-butoxyethyl) phosphate is used as a primary plasticizer for most resins and elastomers, enhancing their flexibility and workability. Its flame-retarding properties make it a valuable additive in this industry, as it helps to reduce the risk of fire and improve the safety of the final products.
Used in Floor Finishes and Waxes:
In the floor finishes and waxes industry, Tris(2-butoxyethyl) phosphate is used to improve the performance and durability of these products. Its flame-retarding properties also contribute to the safety of floor finishes and waxes, making them less likely to ignite and cause fires.
Used as a Flame-Retarding Agent:
Tris(2-butoxyethyl) phosphate is used as a flame-retarding agent in various applications, including in the manufacturing of textiles, electronics, and construction materials. Its ability to slow down the spread of fire and reduce the intensity of flames makes it a crucial component in fire safety measures.

Air & Water Reactions

Water soluble.

Reactivity Profile

Organophosphates, such as Tris(2-butoxyethyl) phosphate, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides. Tris(2-butoxyethyl) phosphate may react with oxidizers. .

Fire Hazard

Tris(2-butoxyethyl) phosphate is combustible.

Flammability and Explosibility


Safety Profile

A poison by intravenous route. Moderately toxic by ingestion. A skin and eye irritant. Combustible when exposed to heat or flame. Dangerous; see also PHOSPHATES; can react with oxidizing materials. To fight fire, use water, foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of POx.

Check Digit Verification of cas no

The CAS Registry Mumber 78-51-3 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 7 and 8 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 78-51:
63 % 10 = 3
So 78-51-3 is a valid CAS Registry Number.

78-51-3 Well-known Company Product Price

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  • Aldrich

  • (130591)  Tris(2-butoxyethyl)phosphate  94%

  • 78-51-3

  • 130591-100G

  • 610.74CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017


1.1 GHS Product identifier

Product name tris(2-butoxyethyl) phosphate

1.2 Other means of identification

Product number -
Other names KP 140

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:78-51-3 SDS

78-51-3Synthetic route



tris(2-butoxyethyl) phosphate

tris(2-butoxyethyl) phosphate

With magnesium chloride; trichlorophosphate at 50 - 80℃; for 5h; Reagent/catalyst; Temperature; Large scale;98%
With quinoclamine; hydroquinone; trichlorophosphate
With trichlorophosphate at 45 - 50℃;
tris(2-butoxyethyl) phosphate

tris(2-butoxyethyl) phosphate





With sodium metabisulfite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; manganese; tetrabutylammomium bromide In dimethyl sulfoxide at 120℃; for 15h; Inert atmosphere;48%

78-51-3Upstream product

78-51-3Downstream Products

78-51-3Relevant articles and documents

A high-purity (butoxy ethyl) phosphate ester industrial preparation method (by machine translation)


Paragraph 0047-0087, (2019/11/04)

The invention relates to a high-purity (butoxy ethyl) phosphate ester of preparation method, the method comprises the following steps: 1) the vacuum condition through the phosphorus oxychloride and ethylene glycol monobutyl ether in the Lewis catalyst under the action of reaction; 2) after the reaction, vacuum-recycle a large amount of glycol flatting, reactant in ethylene glycol monobutyl ether content in the range of 5 - 10%, stop distilling; 3) alkali to neutralize, in and to PH=5 - 8, then distilled under reduced pressure, until the ethylene glycol monobutyl ether content is less than 0.1% stop distilling, to obtain crude; 4) washing the crude product is separated, washed in addition to the water of the product is distilled under reduced pressure to obtain high-purity (butoxy ethyl) phosphate ester. The method of the invention is simple, the purity of the product, in color, to improve the yield is very large. (by machine translation)

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