78000-47-2Relevant articles and documents
SYNTHESIS OF SOME HETEROCYCLES FROM DEHYDRO-L-ASCORBIC ACID AND THEIR BIOLOGICAL ACTIVITY
Mancy, Sohila H.,Sekily, Mohamed A. El,Daghfag, Hager Al,Ali, Om Kolthoom A.
, p. 5 - 11 (2007/10/02)
Synthesis of some heterocyclic compounds from dehydro-L-ascorbic acid, monoaryl hydrazone and their biological activities are described. Key words: Nitrogenheterocycles, Dehydro-L-ascorbic acid, Biological activity.
Isomerization of Phenylhydrazones of Dehydroascorbic Acid
Pedersen, Bjorn
, p. 429 - 434 (2007/10/02)
The structure and dynamics of some para substituted dehydroascorbic acid (DHA) phenylhydrazones in solution have been studied by 13C NMR spectroscopy.Two isomers are observed in N,N-dimethylformamide solution.The standard free energy difference (ΔG) between the two isomers is found to be 0.7 +/- 0.2 kJ/mol and the free energy barrier (ΔG) 62 +/- 2 kJ/mol.The phenylhydrazine group is coplanar with the DHA lactone ring and the N-H group is engaged in a weak hydrogen bond to one of the α carbonyl groups in both isomers.The most stable isomer has the same structure as observed previously for the molecule in the crystalline state.The phenylhydrazones of some simple aldoses (mannose, arabinose, xylose and glycoaldehyde) have been studied for comparison.Only one isomer was detected.The hydrazones were made by adding a phenylhydrazone to a solution of DHA or an aldose.Hydrazides were detected as intermediates.