78000-47-2

Upstream product

• 111399-75-8 dehydro-L-ascorbic acid 
• 100-16-3 4-nitrophenylhydrazone 
• 490-83-5 L-dehydroascorbic acid 

Downstream Products

• 84374-04-9 (R)-5-((S)-1,2-Dihydroxy-ethyl)-3-[(4-nitro-phenyl)-hydrazono]-furan-2,4-dione 4-oxime 
• 162638-94-0 3-(L-threo-glycerol-1-yl)-4,5(1H)-pyrazolinedione 4-(p-nitrophenylhydrazone) 
• 162639-01-2 3-hydroxymethyl-4,5(1H)-pyrazolinedione 4-(p-nitrophenylhydrazone) 
• 162639-00-1 3-formyl-4,5(1H)-pyrazolinedione 4-(p-nitrophenylhydrazone) 
• 162638-93-9 L-threo-2,3-hexodiulosono-1,4-lactone 2-(p-nitrophenylhydrazone)-3-semicarbazone 
• 84374-15-2 Acetic acid (1S,2S)-2,3-diacetoxy-1-[5-acetylcarbamoyl-2-(4-nitro-phenyl)-2H-[1,2,3]triazol-4-yl]-propyl ester 
• 84374-12-9 Acetic acid (1S,2S)-2,3-diacetoxy-1-[5-carbamoyl-2-(4-nitro-phenyl)-2H-[1,2,3]triazol-4-yl]-propyl ester 
• 84374-07-2 Acetic acid (S)-2-acetoxy-1-[(R)-2-(4-nitro-phenyl)-6-oxo-2,6-dihydro-4H-furo[3,4-d][1,2,3]triazol-4-yl]-ethyl ester 
• 84374-26-5 Acetic acid 5-acetylcarbamoyl-2-(4-nitro-phenyl)-2H-[1,2,3]triazol-4-ylmethyl ester 
• 84374-10-7 2-(4-Nitro-phenyl)-5-((1S,2S)-1,2,3-trihydroxy-propyl)-2H-[1,2,3]triazole-4-carboxylic acid amide 
• 84374-23-2 Acetic acid 5-carbamoyl-2-(4-nitro-phenyl)-2H-[1,2,3]triazol-4-ylmethyl ester 
• 84374-20-9 5-Hydroxymethyl-2-(4-nitro-phenyl)-2H-[1,2,3]triazole-4-carboxylic acid amide 
• 84374-18-5 5-Formyl-2-(4-nitro-phenyl)-2H-[1,2,3]triazole-4-carboxylic acid amide 

Relevant academic research and scientific papers

SYNTHESIS OF SOME HETEROCYCLES FROM DEHYDRO-L-ASCORBIC ACID AND THEIR BIOLOGICAL ACTIVITY

Synthesis of some heterocyclic compounds from dehydro-L-ascorbic acid, monoaryl hydrazone and their biological activities are described. Key words: Nitrogenheterocycles, Dehydro-L-ascorbic acid, Biological activity.

STUDIES ON DEHYDRO-L-ASCORBIC ACID 2-ARYLHYDRAZONE 3-OXIMES: CONVERSION INTO SUBSTITUTED TRIAZOLES AND ISOXAZOLINES

L-threo-2,3-Hexodiulosono-1,4-lactone 2-(arylhydrazones) (2) were prepared by condensation of dehydro-L-ascorbic acid with various arylhydrazines.Reaction of 2 with hydroxilamine gave the 2-arylhydrazone) 3-oximes (3).On boiling with acetic anhydride, 3 g

Isomerization of Phenylhydrazones of Dehydroascorbic Acid

The structure and dynamics of some para substituted dehydroascorbic acid (DHA) phenylhydrazones in solution have been studied by 13C NMR spectroscopy.Two isomers are observed in N,N-dimethylformamide solution.The standard free energy difference (ΔG) between the two isomers is found to be 0.7 +/- 0.2 kJ/mol and the free energy barrier (ΔG) 62 +/- 2 kJ/mol.The phenylhydrazine group is coplanar with the DHA lactone ring and the N-H group is engaged in a weak hydrogen bond to one of the α carbonyl groups in both isomers.The most stable isomer has the same structure as observed previously for the molecule in the crystalline state.The phenylhydrazones of some simple aldoses (mannose, arabinose, xylose and glycoaldehyde) have been studied for comparison.Only one isomer was detected.The hydrazones were made by adding a phenylhydrazone to a solution of DHA or an aldose.Hydrazides were detected as intermediates.