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An Improved General Synthesis of 4-Aryl-5-pyrimidinecarboxylates
Breaux, Eves J.,Zwikelmaier, Kurt E.
, p. 183 - 184 (2007/10/02)
We wish to report an improved, general synthesis of 4-aryl-5-pyrimidinecarboxylates 1.Two different routes have previously been reported for the synthesis of examples of this class of pyrimidine carboxylates.The parent compound, ethyl 4-phenyl-5-pyrimidinecarboxylate was prepared in low yield by the reaction of s-triazine with ethyl benzoyl acetate.In addition, the enol ether β-ketoaldehyde synthon, ethyl 2-benzoyl-3-ethoxy-2-propenoate, was reported to give 1a in modest yield when reacted with guanidine (2).
