78007-35-9

Upstream product

• 77-77-0 Divinyl sulfone 
• 587-04-2 m-Chlorobenzaldehyde 
• 41011-01-2 2-bromo-1-(3-chloro-phenyl)-ethanone 
• 99-02-5 3'-Chloroacetophenone 

Relevant academic research and scientific papers

Copper(I)/DDQ-Mediated Double-Dehydrogenative Diels-Alder Reaction of Aryl Butenes with 1,4-Diketones and Indolones

A copper(I)/DDQ-mediated double-dehydrogenative Diels-Alder (DDDA) reaction of simple butenes with 1,4-diketones and indolones has been established for the first time. This strategy is based on a tandem double-dehydrogenation/Diels-Alder reaction from nonprefunctionalized starting materials, in which both a diene and dienophile were in situ generated via activation of fourfold inert C(sp3)-H bonds in one catalytic system.

Visible-light-induced Ci-S bond activation: Facile access to 1,4-diketones from β-ketosulfones

A novel method for the synthesis of 1,4-diketones from β-ketosulfones was developed by means of a visible light-induced Ci￡S bond activation process. Symmetrical and unsymmetrical 1,4-diketones can be easily prepared in moderate to good yields. A new and efficient method for the synthesis of 1,4-diketones from β-ketosulfones was developed by means of a visible-light-induced Ci￡S bond activation process (see scheme). Symmetrical and unsymmetrical 1,4-diketones can be easily prepared in moderate to good yields.

Acylguanidine inhibitors of β-secretase: Optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets

Proteolytic cleavage of amyloid precursor protein by β-secretase (BACE-1) and γ-secretase leads to formation of β-amyloid (Aβ) a key component of amyloid plaques, which are considered the hallmark of Alzheimer's disease. Small molecule inhibitors of BACE-1 may reduce levels of Aβ and thus have therapeutic potential for treating Alzheimer's disease. We recently reported the identification of a novel small molecule BACE-1 inhibitor N-[2-(2,5-diphenyl-pyrrol-1-yl)-acetyl]guanidine (3.a.1). We report here the initial hit-to-lead optimization of this hit and the SAR around the aryl groups occupying the S1 and S2′ pockets leading to submicromolar BACE-1 inhibitors.

Studies of the electron-promoted cope cyclization of 2,5-phenyl-substituted 1,5-hexadiene radical anions

This work describes studies of the electron-promoted Cope cyclization of 2,5-phenyl-1,5-hexadiene radical anions in a flowing afterglow triple quadrupole mass spectrometer. The electronic properties of the hexadienes have been systematically modified by u

One-step preparation of symmetrical 1,4-diketones from α-halo ketones in the presence of Zn-I2 as a condensation agent

Eleven 1,4-diphenylbutane-1,4-diones have been prepared in one step from the corresponding α-halo acetophenones under the action of Zn-I 2 as a condensation agent with moderate to high yields. The mechanistic pathway of the reaction can be explained by the Wurtz-like self-condensation of α-halo ketones. Similarly, 3-chloropentane-2,4-dione gave 3,4-diacetylhexane-2,5-dione, a Wurtz-like condensation product.

Addition von Aldehyden an aktivierte Doppelbindungen, XXIX. Neue Methode zur Darstellung symmetrischer 1,4-Diketone

Thiazolium salt-catalysed addition of aliphatic, aromatic, and heterocyclic aldehydes to phenyl vinyl sulfone yields in a three-step addition-elimination mechanism 1,4-diketones (1 - 3) and 1,4-disulfone (23).The analogous reaction with divinyl sulfone leads in good yields to the corresponding 1,4-diketones (1 - 22).