78010-09-0Relevant academic research and scientific papers
"Crowned" Fe4S4 Clusters as Electrochemical Metal Ion Sensors
Gebbink, Robertus J. M. Klein,Klink, Stephen I.,Feiters, Martinus C.,Nolte, Roeland J. M.
, p. 253 - 264 (2007/10/03)
A series of Fe4S4 cluster compounds I, III, and V, in which the cuboidal cluster core is appended with four crown ether thiolate ligands, and II and IV, bearing thiolate ligands without crown ether parts, has been synthesized and characterized. The spectroscopic and electrochemical properties of these compounds are determined by the electronic nature of the thiolate ligands. Only in the case of III, where a very short α-thioacetyl linker was used to connect the crown ether ligands to the cluster core, was a restricted conformational freedom of the ligand observed. A detailed electrochemical study of the influence of alkali and earth alkali metal ions (Li+, Na+, K+, Mg2+, and Ba2+) on the reversible 2-/3- reduction of the cluster compounds was performed. In the case of the crown ether appended clusters I,III, and V, the addition of these metal ions resulted in an anodic shift, i.e. in positive direction, of the reduction potential (modulation effect) and to larger current responses (promotion effect). The magnitude of the modulation effects is determined by the binding affinity of the metal ions in the crown ether ligands, and by the distance between bound metal ions and the redox active cluster core. Variation of the linker between the cluster core and the metal ion binding site resulted in cluster compounds with almost inverse selectivities for e.g. K+ and Ba2+ in the case of I and III. For the large effects found for compound I a lariat binding mode is proposed.
Synthesis and Antibacterial Activity of 2,2'-Dithiobis(benzamide) Derivatives against Mycobacterium Species
Okachi, Ryo,Niino, Hideki,Kitaura, Kozo,Mineura, Kazuyuki,Nakamizo, Yoshinobu,et al.
, p. 1772 - 1779 (2007/10/02)
A series of compounds, which are analogues of 2,2'-dithiobis(benzamide), were synthesized and tested for in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv including resistant strains against streptomycin, kanamycin, or isonicotinic acid hydrazide.MICs of these compounds against a typical mycobacteria, Mycobacterium kansasii and Mycobacteruim intracellulare were also examined.Structure-activity relationships were found in a series of (acyloxy)alkyl ester derivatives depending upon the length of alkyl carbon chain.The MIC of the most potent compound , 2,2'-dithiobisbenzamide> was superior or at least equivalent to streptomycin, kanamycin, and ethanbutol.All the compounds showed no cross-resistance between the current antitubercular agents.
