78019-25-7

Upstream product

• 78019-18-8 Methyl (2R^*,4S^*)-2-bromo-4-methyl-5-hexenoate 
• 78019-23-5 (2R,4R)-2-Formyloxy-4-methyl-hex-5-enoic acid methyl ester 
• 78019-24-6 Methyl (2S^*,4S^*)-2-hydroxy-4-methyl-5-hexenoate 
• 98-59-9 p-toluenesulfonyl chloride 

Relevant academic research and scientific papers

Stereospecific Syntheses of Both Diastereomers of (+/-)-2-Amino-4-methyl-5-hexenoic Acid.

Both diastereomers of 2-amino-4-methyl-5-hexenoic acid (7 and 16) have been synthesized stereospecifically from methyl (2R*,4S*)-2-bromo-4-methyl-5-hexenoate (1), the product of the EtAlCl2-catalyzed ene reaction of methyl α-bromoacrylate and trans-2-butene.This synthesis establishes the stereochemistry of the ene reaction and establishes that the amino isolated from a Streptomyces fermentation is 7.