78025-68-0

Usage

Uses

Used in Pharmaceutical Industry:
4-O-DesMethyl 4-O-Ethyl TriMethopriM is used as an antibacterial agent for treating patients with urinary tract infections. It is often prescribed alongside Sulfametoxazole to enhance the effectiveness of treatment and combat bacterial infections more efficiently.
Additionally, due to its potential antibacterial activity, 4-O-DesMethyl 4-O-Ethyl TriMethopriM may be utilized in the development of new medications or therapies targeting various bacterial infections in different areas of medicine.

Upstream product

• 39075-25-7 3,5-Dimethoxy-4-ethoxybenzaldehyde 
• 593-85-1 diguanidine carbonate 
• 2141-62-0 3-(ethoxy)propionitrile 
• 110-67-8 3-Methoxypropionitrile 
• 506-93-4 guanidine nitrate 
• 134-96-3 syringic aldehyde 

Relevant academic research and scientific papers

Preparation method of trimethoprim impurities

The invention relates to a preparation method of trimethoprim impurities. The method can be used for preparing trimethoprim impurities A, E, F and G. Cyclizing agents, such as guanidine nitrate or methylguanidine hydrochloride, are taken as raw materials, and are condensed with trimethoprim methyl ether of different structures to stably obtain various kinds of trimethoprim impurities. The method is simple and available in raw material, short in reaction time and high in yield.

Separation, analyses and syntheses of trimethoprim impurities

The analysis of several impurities of the chemotherapeutic agent trimethoprim with various methods, including thin layer chromatography, gas chromatography, capillary electrophoresis as well as nuclear magnetic resonance is described. These methods were used to identify new impurities in trimethoprim batches. The main impurities were separated by column chromatography. To ensure the identity of the impurities, de novo syntheses were successfully carried out. With the methods described, it was possible to detect, separate and identify new impurities in trimethoprim batches.