110-67-8Relevant articles and documents
Phosphine-catalyzed hydration and hydroalkoxylation of activated olefins: Use of a strong nucleophile to generate a strong base
Stewart, Ian C.,Bergman, Robert G.,Toste, F. Dean
, p. 8696 - 8697 (2003)
The direct addition of water and a variety of alcohols to activated olefins was observed in the presence of nucleophilic phosphine catalysts. Unlike existing methods, the reactions proceed at room temperature and in the absence of transition metals, or strong acids or bases. The use of simple commercially available catalysts makes this an attractive method for the preparation of β-hydroxy and β-alkoxy substrates, which are prevalent targets and intermediates in organic synthesis. The scope and mechanism of this reaction has been explored, and the compound that acts as the resting state of the catalyst was synthesized independently. Our mechanism also suggests the possibility of extending the scope of this reactivity to other classes of nucleophiles. Copyright
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Ogata et al.
, p. 5426 (1956)
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Preparation method of 3-methoxypropylamine
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Paragraph 0047-0049; 0055-0056; 0058-0059; 0061-0062; ..., (2021/06/23)
The invention discloses a preparation method of 3-methoxylpropylamine. The method comprises the following steps: carrying out addition on methanol and acrylonitrile to prepare a 3-methoxylpropionitrile crude product, and then carrying out catalytic hydrogenation on the crude product by using a Raney catalyst to prepare the 3-methoxylpropylamine. In the addition reaction, through air protection and gradient temperature reaction control, the acrylonitrile conversion rate of the addition reaction can be increased, generation of hydrogenation reaction by-products is reduced, the acrylonitrile conversion rate is larger than 99.6%, the yeild of the 3-methoxylpropylamine is larger than 99.1% and residual quantity of acrylonitrile in the crude product is smaller than 0.3%; and the hydrogenation reaction raw materials do not need to be refined, an alkaline auxiliary agent does not need to be additionally added, the average yield of MOPA can reach 96.5%, and the catalyst can be recycled for more than 30 batches.
Preparation method of gamma-methoxypropylamine
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Paragraph 0025; 0027-0028; 0036-0037; 0045-0046; 0054-0055, (2019/03/28)
The invention provides a preparation method of gamma-methoxypropylamine, which is high in conversion rate. The invention adopts the following technical scheme: the preparation method of the gamma-methoxypropylamine, comprising the following steps: preparing 3-methoxypropionitrile by using acrylonitrile and sodium methoxide as raw materials; and by taking the 3-methoxypropionitrile as a raw material, preparing the gamma-methoxypropylamine in the presence of an amine reagent, a nickel catalyst and silver nitrate in a reducing manner. The raw materials are high in utilization rate; the separationprocess is simple and clear; the energy consumption is low; the production cost of a product is low; and the solvent and the catalyst can be recycled for use.
Synthesis method of 3-methoxyl-N, N-dimethylacrylamide
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Paragraph 0039; 0042-0044, (2017/07/22)
The invention relates to a synthesis method of 3-methoxyl-N, N-dimethylacrylamide, and belongs to the technical field of chemical synthesis. The synthesis method comprises the following steps of adding 3-methoxypropionic acid and dimethylamine into a sealed reactor; raising the temperature to 80 to 150 DEG C; performing reaction to obtain 3-methoxyl-N, N-dimethylacrylamide, wherein the pressure in the sealed reactor is 0.1 to 10.0MPa. The 3-methoxypropionic acid is used as the raw materials to perform high-temperature dewatering with dimethylamine in a sealed reaction vessel; polyhydric alcohol and basic catalysts are not needed; the reaction is simple; the implementation is easy; the yield of a product is high; the purity is high; the high yield is realized; meanwhile, the pollution is little; the cost is low; the method conforms to the requirements of modern chemical green synthesis. Meanwhile, the 3-methoxypropionic acid uses low-price acrylonitrile as the starting raw materials; the acrylonitrile is subjected to alkoxylation to obtain methoxyl propionitrile; then, hydrolysis is performed. The operation is simple; the energy consumption is low.