78033-08-6 Usage
Uses
Used in Pharmaceutical Industry:
8-METHOXYMETHYL-3-ISOBUTYL-1-METHYLXANTHINE is used as a specific inhibitor for calmodulin-sensitive cyclic GMP phosphodiesterase for its ability to regulate the activity of this enzyme. This inhibition can be beneficial in the development of drugs targeting various diseases and conditions where the regulation of cyclic GMP is crucial.
Used in Research and Development:
In the field of research and development, 8-METHOXYMETHYL-3-ISOBUTYL-1-METHYLXANTHINE is used as a selective PDE1 inhibitor to study the role of phosphodiesterase enzymes in cellular processes and signaling pathways. This can help in understanding the underlying mechanisms of various diseases and contribute to the development of novel therapeutic strategies.
Used in Drug Design and Development:
8-METHOXYMETHYL-3-ISOBUTYL-1-METHYLXANTHINE is used as a lead compound in drug design and development due to its selective inhibition of PDE1. This property can be exploited to create new drugs with improved specificity and efficacy, targeting a wide range of medical conditions.
Used in Diagnostic Applications:
In the diagnostic industry, 8-METHOXYMETHYL-3-ISOBUTYL-1-METHYLXANTHINE can be used as a tool to study the activity of calmodulin-sensitive cyclic GMP phosphodiesterase in various samples. This can help in the identification and monitoring of diseases and conditions related to the dysregulation of this enzyme.
Biological Activity
Specific inhibitor of calmodulin-sensitive cyclic GMP phosphodiesterase (IC 50 = 5.2 μ M).
Biochem/physiol Actions
Selective inhibitor of Ca2+-calmodulin-dependent phosphodiesterase I (PDE1).
Check Digit Verification of cas no
The CAS Registry Mumber 78033-08-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,8,0,3 and 3 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 78033-08:
(7*7)+(6*8)+(5*0)+(4*3)+(3*3)+(2*0)+(1*8)=126
126 % 10 = 6
So 78033-08-6 is a valid CAS Registry Number.
InChI:InChI=1/C12H18N4O3/c1-7(2)5-16-10-9(11(17)15(3)12(16)18)13-8(14-10)6-19-4/h7H,5-6H2,1-4H3,(H,13,14)
78033-08-6Relevant academic research and scientific papers
Xanthines, optionally incorporated in liposomes, for promoting skin or hair pigmentation
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, (2008/06/13)
A method of treating skin or hair for promoting pigmentation wherein a xanthine component, in an amount effective to promote pigmentation, is incorporated in liposomes or hydrated lipidic lamellar phases.
New xanthine derivatives with potent and long lasting anti-bronchoconstrictive activity
Regnier, Gilbert L.,Guillonneau, Claude G.,Duhault, Jacques L.,Tisserand, Francoise P.,Saint-Romas, Guy,Holstorp, Sophie M.
, p. 243 - 250 (2007/10/02)
Twenty eight new derivatives of 8-aminoalkyl substituted xanthine have been synthesized.They all have demonstrated a potent anti-bronchoconstrictive effect in the guinea pig and some of them have a very long duration of action (>48 h).Among them, one compound: 1-methyl 3-isobutyl 8-(4-benzhydryl piperazino ethyl)xanthine (57) (S 9795) has been selected for clinical trials in asthmatic patients because of its long duration of action, its lack of CNS stimulating effects and its inhibiting action on mast cell degranulation and phosphodiesterase activity.Keywords - 8-aminoalkyl substituted xanthines / benzhydryl piperazine / piperidine / ethylenediamine / anti-bronchoconstrictors / phosphodiesterase inhibitors / asthma
