78045-89-3

Upstream product

• 16951-33-0 3-amino-2,3-dihydro-2-thioxoquinazol-4(1H)-one 
• 70-11-1 α-bromoacetophenone 
• 29025-05-6 3-Acetamido-2-mercaptoquinazolin-4(3H)-one 
• 16951-33-0 3-amino-2-mercapto-3H-quinazolin-4-one 
• 118-48-9 isatoic anhydride 
• 78045-79-1 3-amino-2-[[2-phenyl-2-oxoethyl]thio]-4(3H)-quinazolinone 
• 28864-26-8 acetylhydrazide de l'acide anthranilique 

Downstream Products

• 121007-08-7 2-Phenyl-4-H-9-oxo-pyrazolo<5,1-b>quinazoline 

Relevant academic research and scientific papers

Pyrolytic desulfurization ring contraction of condensed thiadiazines as a general route towards pyrazoloazines and pyrazoloazoles with a bridgehead (ring junction) nitrogen atom

Pyrolytic conversion of [1,2,4]triazino[3,4-b][1,3,4]thiadiazin-4-ones, [1,3,4]thiadiazino[2,3-b]quinazolin-10-ones and [1,2,4]triazolo[3,4-b][1,3,4]thiadiazines into their corresponding pyrazolo[5,1-c][1,2,4]triazin-4-ones, pyrazolo[4,3-b]quinazolin-9-on

Synthesis and pharmacological screening of 1,3,4-thiadiazino[2,3-b]quinazoline derivatives

Derivatives of 1,3,4-thiadiazino[2,3-b]quinazoline 7, 9, 9a, 12, 12a, and 13 were prepared from the 3-amino-6-bromo-2,3-dihydro-2-thioxo-4-(1H)-quinazolinone (2) and its analogue without bromine. A series of the title derivatives with or without bromine w

Syntheses of novel 3-amino-2(1H)-thioxo-4(3H)-quinazolinones and evaluation of their immunotropic activity. Part III

The synthesis of two series of derivatives containing the quinazolinone-4 moiety is described. 3-Amino-2(1H)-thioxo-4(3H)-quinazolinone(1) was subjected to reactions with halogenoketones and halogenoaldehydes, leading to the production of the corresponding ketones, aldehydes, Schiff bases, and 6-oxo-1,4,5-thiadinzin[2,3-b]quinazoline derivatives. Subsequently, 1 was condensed with selected α,β-unsaturated carbonyl compounds, aldehydes, ketones, acid chlorides, and esters. The compounds were tested for their potential activity in a model of humoral and cellular immune response. The tests showed that the compounds exhibited differential immunotropic activities. Of particular interest is compound 19, exhibiting a strong stimulatory activity with regard to cellular immune response and compound 16 exerting a strong inhibitory action in both types of the immune response.

Synthesis of Thiadiazinoquinazolin-6-ones

Some 3-substituted 2H-thiadiazinoquinazolin-6(H)-ones (Xa-e) and 6H-thiadiazinoquinazolin-6(4H)-ones (XIa-e) have been synthesized by the condensation of α-haloacetophenones (VIII) with 3-amino-2-mercaptoquinazolin-4(3H)-one (V