16951-33-0Relevant articles and documents
Synthesis and Antioxidant Evaluation of Quinoxalino[2′,3′:5,6][1,3,4]thiadiazino[2,3-b]quinazolin-15-ones: Derivatives of a Novel Ring System
Mousavi, Mahsa,Bakavoli, Mehdi,Shiri, Ali,Eshghi, Hossein
, p. 517 - 521 (2018)
Quinoxalino[2′,3′:5,6][1,3,4]thiadiazino[2,3-b]quinazolin-15-one, a novel fused heterocyclic system, was synthesized from a one-pot condensation reaction of 2,3-dichloroquinoxaline and 3-amino-2-thioxo-2,3-dihydroquinazolin-4(1H)-one under mild condition. Derivatization was performed on treatment of the titled compound with several alkyl bromides. In vitro antioxidant activity of the synthesized compounds was evaluated.
Synthesis and reactivity of 1,2,4-triazolo[1,5-c]quinazolines
Pfeifer, Wolf-Diethard,Hetzheim, Annemarie,Pazdera, Pavel,Bodtke, Anja,Mücke, Jana
, p. 1327 - 1336 (1999)
The preparation of 1,2,4-triazolo[1,5-c]quinazolines 4a-d, 5, 8a-d by cyclocondensation of 1a-c with carboxylic acids and carboxylic anhydrides, respectively, is described. By different pathways, the 5-thioxo-5,6-dihydro- 1,2,4-triazolo[1,5-c]quinazolines
Synthesis of some quinazolinones inspired from the natural alkaloid L-norephedrine as EGFR inhibitors and radiosensitizers
Ghorab, Mostafa M.,Abdel-Kader, Maged S.,Alqahtani, Ali S.,Soliman, Aiten M.
, p. 218 - 237 (2021)
A set of quinazolinones synthesized by the aid of L-norephedrine was assembled to generate novel analogues as potential anticancer and radiosensitizing agents. The new compounds were evaluated for their cytotoxic activity against MDA-MB-231, MCF-7, HepG-2, HCT-116 cancer cell lines and EGFR inhibitory activity. The most active compounds 5 and 6 were screened against MCF-10A normal cell line and displayed lower toxic effects. They proved their relative safety with high selectivity towards MDA-MB-231 breast cancer cell line. Measurement of the radiosensitizing activity for 5 and 6 revealed that they could sensitize the tumour cells after being exposed to a single dose of 8 Gy gamma radiation. Compound 5 was able to induce apoptosis and arrest the cell cycle at the G2-M phase. Molecular docking of 5 and 6 in the active site of EGFR was performed to gain insight into the binding interactions with the key amino acids.
QUINAZOLINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO
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Page/Page column 40; 41, (2014/01/07)
The disclosure relates to quinazoline derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to inhibitors of NADPH-oxidases (Nox enzymes) and/or myeloperoxidase.
