78057-61-1

Upstream product

• 50515-48-5 (R)-5-(benzyloxy)-4-{(S)-2-[(tert-butoxycarbonyl)amino]propanamido}-5-oxopentanoic acid 

Downstream Products

• 78057-59-7 O¹-benzyl-N-(N-lauroyl-L-alanyl)-D-glutamic acid 
• 78057-80-4 N²-1-benzyl-N-(N-lauroyl-L-alanyl)-γ-D-glutamyl>-N⁶-benzyloxycarbonyl-L-2,6-diaminopimelamic acid 
• 78057-77-9 RP 56142 

Relevant academic research and scientific papers

Synthesis of RP 56142: a New Immunoactive Peptide

RP 56142, a new immunoactive peptide was synthesized on large scale (ca. 500 g) via L-2,6-diaminopimelic acid which was prepared by chemical or biochemical synthesis.The key derivative, N6-benzyloxycarbonyl-L-2,6-diaminopimelamic acid was synthesized by two methods.In the first, we used a copper chelate procedure.In the second, we selectively deblocked the amine at the α-position to the free carboxylic group by the N-carboxyanhydride method.Condensation of N6-benzyloxycarbonyl-L-2,6-diaminopimelamic acid and the appropriately protected lauroyl dipeptide and removal of the protecting groups afforded RP 56142.