78060-54-5

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloroquinoline-6-carbonitrile is used as an intermediate in the production of antimalarial drugs. Its unique structure allows for the development of new therapeutic agents that can combat malaria, a significant global health concern.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Chloroquinoline-6-carbonitrile serves as a key intermediate for the synthesis of insecticides. Its incorporation into these products helps in the development of effective crop protection solutions, ensuring agricultural productivity and food security.
Overall, 2-Chloroquinoline-6-carbonitrile's potential for the development of new therapeutic agents and crop protection products makes it a valuable compound in the fields of medicinal and agricultural chemistry.

InChI:InChI=1/C10H5ClN2/c11-10-4-2-8-5-7(6-12)1-3-9(8)13-10/h1-5H

Upstream product

• 63124-11-8 2-oxo-1H-quinoline-6-carbonitrile 
• 1810-66-8 6-bromoquinoline-2-ol 
• 1810-71-5 6-bromo-2-chloroquinoline 
• 327058-51-5 N-(4-bromophenyl)-(E)-3-ethoxyacrylamide 
• 1810-66-8 6-bromo-2-quinolone 

Downstream Products

• 1431869-10-1 tert-butyl 4-(6-cyanoquinolin-2-yl)-3-oxopiperazine-1-carboxylate 
• 676131-31-0 (R)-2-(3-methylpiperazin-1-yl)quinoline-6-carbonitrile 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUNDS AND USES THEREOF

Provided herein are novel heterocyclic compounds, for example, compounds having Formula I, I-P, II, lI-P, or III. Also provided herein are pharmaceutical compositions comprising the compounds and methods of using the same, for example, in inhibiting aldehyde dehydrogenases and/or for treating various cancers, cancer metastasis, type 2 diabetes, pulmonary arterial hypertension (PAH) or neointimal hyperplasia (NIH).

UREA AND THIOUREA SUBSTITUTED BICYCLES DERIVATIVES AS PESTICIDES

The present invention relates to compounds of formula (I) a compound of formula (1') as defined herein, to processes for preparing them, to pesticidal, in particular insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them and

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula I I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds act as diuretics and natriuretics and are valuable pharmaceutically active compounds for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension and conditions resulting from excessive salt and water retention.

2-(4-Alkylpiperazin-1-yl)quinolines as a new class of imidazole-free histamine H3 receptor antagonists

With the aim of identifying structurally novel, centrally acting histamine H3 antagonists, a series of 2-(4-alkylpiperazin-1-yl)quinolines was prepared. Systematic variation of the substituents led to highly potent histamine H3 antagonists with low polar surface area and appropriate log P for blood-brain barrier penetration.