78069-67-7 Usage
Derivative of pyrrole
This indicates that the compound is derived from the pyrrole molecule, which is a five-membered aromatic ring with one nitrogen atom.
Nitro group
This is a functional group consisting of an oxygen atom bonded to a nitrogen atom, which is present in the compound and contributes to its reactivity.
Methyl group
This is a functional group consisting of a carbon atom bonded to three hydrogen atoms, which is present in the compound and contributes to its reactivity.
Pale yellow solid
This is the physical state and color of the compound, which can be useful for identification purposes.
Molecular weight
125.13 g/mol This is the mass of one mole of the compound, which is a useful physical property for determining the amount of substance in a given sample.
Potential applications in organic synthesis and medicinal chemistry
This indicates that the compound has potential uses in the synthesis of other organic compounds and in the development of pharmaceuticals.
Versatile building block
This suggests that the compound can be used in a variety of chemical reactions to synthesize a wide range of organic compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 78069-67-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,8,0,6 and 9 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 78069-67:
(7*7)+(6*8)+(5*0)+(4*6)+(3*9)+(2*6)+(1*7)=167
167 % 10 = 7
So 78069-67-7 is a valid CAS Registry Number.
78069-67-7Relevant academic research and scientific papers
Tercel,Lee,Hogg,Anderson,Lee,Siim,Denny,Wilson
, p. 3511 - 3522 (2001)
Nitrobenzyl quaternary salts of nitrogen mustards have been previously reported as hypoxia-selective cytotoxins. In this paper we describe the synthesis and evaluation of a series of heterocyclic analogues, including pyrrole, imidazole, thiophene, and pyrazole examples, chosen to cover a range of one-electron reduction potentials (from -277 to -511 mV) and substitution patterns. All quaternary salt compounds were less toxic in vitro than mechlorethamine, and all were more toxic under hypoxic than aerobic conditions, although the differentials were highly variable within the series. The most promising analogue, imidazole 2, demonstrated DNA crosslinking selectively in hypoxic RIF-1 cells, and was active in vivo in combination with radiation or cisplatin. However, 2 also produced unpredictable toxicity in vivo, suggestive of nonspecific nitrogen mustard release, and this has restricted further development of these compounds as hypoxia-selective cytotoxins.
