78069-88-2

Basic information

• Product Name: 1-(3,4-Dimethyl-phenyl)-4-(3-nitro-pyridin-4-yl)-piperazine
• Synonyms: 1-(3,4-Dimethyl-phenyl)-4-(3-nitro-pyridin-4-yl)-piperazine
• CAS NO: 78069-88-2
• Molecular Weight: 312.371
• Mol File: 78069-88-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(3,4-Dimethyl-phenyl)-4-(3-nitro-pyridin-4-yl)-piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,4-Dimethyl-phenyl)-4-(3-nitro-pyridin-4-yl)-piperazine(78069-88-2)
• EPA Substance Registry System: 1-(3,4-Dimethyl-phenyl)-4-(3-nitro-pyridin-4-yl)-piperazine(78069-88-2)

Safety Data

• Hazardous Substances Data: 78069-88-2(Hazardous Substances Data)

Upstream product

• 13091-23-1 4-chloro-3-nitropyridine 
• 1014-05-7 1-(3,4-dimethylphenyl)piperazine 

Downstream Products

• 78069-89-3 4-[4-(3,4-Dimethyl-phenyl)-piperazin-1-yl]-pyridin-3-ylamine 

Relevant articles and documents

Quantitative Structure Activity Relationship in 3,4-Disubstituted Pyridines and 1-(3"-Amino-4"-pyridyl)-4-arylpiperazines

In a study of the SAR in 3,4-disubstituted pyridines, it has been observed that both stimulant and anticonvulsant activities are confined to 1-(3'-amino-4'-pyridyl)-4-phenylpiperazines, and further the substitution in the phenyl ring can dissociate these activities of this prototype.In order to understand the relationship of electronic (?), hydrophobic (?) and stereo (Es) parameters of the substituents with anticonvulsant activity, a multi-parameter regression analysis of twelve compounds of this group has been carried out, which suggests that hydrophobic and electronic factors are more important and anticonvulsant activity can be enhanced by compounds having log P = 2.7- 3.1 0= 2.67 (Eq. 5) and (log P)0= 3.09 (Eq. 6)> with an electron withdrawing substituent in the phenyl ring.