78074-40-5Relevant academic research and scientific papers
α-Alkylation of Ketones with Alkenes Enabled by Photoinduced Activation of Silyl Enol Ethers in the Presence of a Small Amount of Water
Hirata, Tsubasa,Ogasawara, Yoshihiro,Yamashita, Yasuhiro,Kobayashi, Shū
supporting information, p. 5693 - 5697 (2021/08/03)
Under blue-light irradiation conditions with a photocatalyst [1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene], silyl enol ethers reacted with alkenes in the presence of a small amount of water to afford the α-alkylation products in good to high yields. A thiol cocatalyst was found to expand the substrate scope of the reaction.
Reductive Cleavage of Arylcyclopropyl Ketones
Murphy, William S.,Wattanasin, Sompong
, p. 1445 - 1452 (2007/10/02)
Arylcyclopropyl aryl ketones undergo clean but slow reductive cleavage to 4-arylbutyrophenones when heated with zinc in ethanol.Replacement of one the aryl groups by an alkyl group strongly inhibits reaction.This effect is in part overcome by the use of a higher boiling alcohol.When substituted at the cyclopropyl methylene position by an ethoxycarbonyl group these cyclopropyl ketones also undergo cleavage but with the unexpected formation of the ethyl 3,5-diaryl-5-oxopentanoates (22).In general, the results are consistent with the formation of an anion-radical intermediate.
REDUCTIVE CLEAVAGE OF CYCLOPROPYL KETONES
Murphy, William S.,Wattanasin, Sompong
, p. 695 - 698 (2007/10/02)
Aryl substituted cyclopropyl ketones are cleaved to acyclic ketones with zinc and zinc chloride or with zinc alone in refluxing alcohol.
