78078-13-4

Upstream product

• 41467-29-2 3,3-bis(methylthio)-1-(thiophen-2-yl)prop-2-en-1-one 
• 62-53-3 aniline 
• 88-15-3 2-Acetylthiophene 
• 103-72-0 phenyl isothiocyanate 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 
• 18076-44-3 (2-thienylcarbonyl)thioacetanilide 

Downstream Products

• 1360604-03-0 4-(4-fluorophenyl)-2-phenylamino-3-(2-thienoyl)-4H-pyrano[3,2-c]chromen-5-one 
• 1360604-02-9 4-(3-nitrophenyl)-2-phenylamino-3-(2-thienoyl)-4H-pyrano[3,2-c]chromen-5-one 
• 1360603-92-4 7,7-dimethyl-4-(3-nitrophenyl)-2-phenylamino-3-(2-thienoyl)-4,6,7,8-tetrahydrochromen-5-one 
• 1360603-95-7 7,7-dimethyl-4-(4-methoxyphenyl)-2-phenylamino-3-(2-thienoyl)-4,6,7,8-tetrahydrochromen-5-one 
• 1360603-93-5 4-(2,4-dichlorophenyl)-7,7-dimethyl-2-phenylamino-3-(2-thienoyl)-4,6,7,8-tetrahydrochromen-5-one 
• 1360603-94-6 4-(4-bromophenyl)-7,7-dimethyl-2-phenylamino-3-(2-thienoyl)-4,6,7,8-tetrahydrochromen-5-one 
• 1619943-26-8 2-(methylthio)-1-phenyl-3-(2-thienoyl)-4-(p-tolyl)pyrrole 
• 1619943-25-7 1,4-diphenyl-2-(methylthio)-3-(2-thienoyl)pyrrole 

Relevant academic research and scientific papers

One-Pot Mitsunobu Protocol to Access Ketene S,S-/N,S-Acetals at Room Temperature

With unique chemical reactivity, α-oxoketene S,S- and N,S-acetals have attracted enormous attention in the past decades, whereas limited reports exist for their synthesis via eco-compatible protocols. Herein, we developed a one-pot protocol for symmetrical and unsymmetrical α-oxoketene S,S-/N,S-acetals through chemoselective alkylation of α-enolic dithioesters using Mitsunobu chemistry at room temperature. The operationally simple and user-friendly mild protocol tolerates a wide range of alcohols and α-enolic dithioesters/β-ketothioamides. Short reaction time, good yields, highly selective C?S functionalization, and E/Z-stereoselectivity are imperative characteristics of this strategy.

ZnCl2-Catalyzed [4+1] Annulation of Alkylthio-Substituted Enaminones and Enaminothiones with Sulfur Ylides

Concise construction of furan and thiophene units has played an important role in the synthesis of potentially bioactive compounds and functional materials. Herein, an efficient Lewis acid ZnCl2 catalyzed [4+1] annulation of alkylthio-substituted enaminones is reported, that is, α-oxo ketene N,S-acetals with sulfur ylides to afford 2-acyl-3-aminofuran derivatives. In a similar fashion, [4+1] annulation of the corresponding enaminothiones, that is, α-thioxo ketene N,S-acetals, with sulfur ylides efficiently proceeded to give multisubstituted 3-aminothiophenes. This method features wide substrate scopes as well as broad functional group tolerance, offering a concise route to highly functionalized furans and thiophenes.

A Highly Efficient Approach for the Synthesis of Novel Trifluoroacetylated Enaminones using DBU as a Base

An efficient methodology has been developed for the synthesis of a variety of novel trifluoroacetylated enaminones by using trifluoroacetic anhydride in DCE as solvent and DBU as a base via electrophilic trifluoroacetylation. X-ray crystallographic studie

Synthesis of Novel Fluorinated Multisubstituted Pyrimidines and 1,5-Benzodiazepines via Fluorinated N,S-Acetals

An efficient and novel approach using highly versatile but less exploited monofluorinated α-oxoketene N,S-acetals as synthons for the synthesis of novel fluorinated multisubstituted pyrimidines and 1,5-benzodiazepines by cyclization with guanidine nitrate

DABCO-Promoted three-component regioselective synthesis of functionalized chromen-5-ones and pyrano[3,2-c]chromen-5-ones via direct annulation of α-oxoketene-N,S-arylaminoacetals under solvent-free conditions

An efficient and convergent route to 3-aroyl-4-aryl-2-arylamino-4,6,7,8- tetrahydrochromen-5-ones and hitherto unreported 3-aroyl-4-aryl-2-arylamino-4H- pyrano[3,2-c]chromen-5-ones has been developed by an one-pot three-component domino coupling of α-oxok

Reaction of α-oxoketene dithioacetals with arylamines in the presence of BF3-OEt2 for the synthesis of ketene S,N-acetals

Reaction of α-oxoketene dithioacetals with arylamines was accelerated with a catalytic amount of BF3-OEt2 to give the corresponding α-oxoketene S,N-acetals selectively in good yields.