780782-34-5

Upstream product

• 78-84-2 isobutyraldehyde 
• 471-25-0 Propiolic acid 
• 103-49-1 dibenzylamine 
• 590-86-3 isovaleraldehyde 
• 1066-54-2 trimethylsilylacetylene 
• 780782-30-1 (+/-)-N,N-dibenzyl-4-methyl-1-(trimethylsilyl)pent-1-yn-3-amine 

Downstream Products

• 780782-37-8 (+/-)-4-(dibenzylamino)-5-methyl-1-(2,4,5-trifluorophenyl)hex-2-yn-1-one 
• 780782-39-0 (+/-)-(4-chlorophenyl)-4-(dibenzylamino)-5-methylhex-2-yn-1-one 
• 120803-28-3 N,N-dibenzyl-4-methyl-1-phenyl-1-pentyn-3-amine 
• 1360788-79-9 N₃,N₃,N₆,N₆-tetrabenzyl-2,7-dimethyloct-4-yne-3,6-diamine 

Relevant academic research and scientific papers

Copper(I)-catalyzed decarboxylative coupling of propiolic acids with secondary amines and aldehydes

An efficient microwave-assisted synthesis of tertiary propargylamines has been developed by copper(I)-catalyzed decarboxylative A3-coupling reaction of an alkynylcarboxylic acid with a secondary amine and an aldehyde. A wide range of diversely substituted propargylamines could be synthesized in high yields. The optimal reaction conditions are also effective for 3-alkylpropiolic acids and for terminal propiolic acid. Copyright

Copper(I)-catalysed deacetylenative cross-coupling reaction of terminal alkynes with propargylic amines via C(sp)-C(sp3) bond cleavage

The catalytic deacetylenative coupling reaction of terminal alkynes with various N-substituted propargylic amines proceeded in the presence of CuCl (10 mol%) and NaPO(4 equiv) in THF at 130 °C to give the corresponding substituted propargylic amines in go

Monophosphine compound, transition metal complex thereof and production method of optically active compound using the complex as asymmetric catalyst

The present invention provides a compound represented by the formula (I): wherein ring A is void or a benzene ring optionally having substituent(s), R1 and R2 are each independently a phenyl group optionally having substituent(s), a cyclohexyl group and the like, R3 and R4 are each independently a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group and the like, and X is a residue represented by —OR5 or —NHR6 wherein R5 and R6 are a lower alkyl group optionally having substituent(s), an aralkyl group optionally having substituent(s) and the like, a asymmetric transition metal complex containing the compound as a ligand and a production method of optically active compound using the complex as an asymmetric catalyst.

Synthesis of chiral α-aminoalkylpyrimidines using an enantioselective three-component reaction

A range of chiral α-aminoalkylpyrimidines has been prepared in a modular fashion in 5 steps with up to 98% ee. The key step is a CuBr-catalyzed enantioselective asymmetric three-component synthesis of propargylic amines.