78080-33-8Relevant academic research and scientific papers
Chromatography-Free Multicomponent Synthesis of Thioureas Enabled by Aqueous Solution of Elemental Sulfur
Németh, András Gy.,Szabó, Renáta,Domján, Attila,Keser?, Gy?rgy M.,ábrányi-Balogh, Péter
, p. 16 - 27 (2020/12/31)
The development of a new three-component chromatography-free reaction of isocyanides, amines and elemental sulfur allowed us the straightforward synthesis of thioureas in water. Considering a large pool of organic and inorganic bases, we first optimized the preparation of aqueous polysulfide solution from elemental sulfur. Using polysulfide solution, we were able to omit the otherwise mandatory chromatography, and to isolate the crystalline products directly from the reaction mixture by a simple filtration, retaining the sulfur in the solution phase. A wide range of thioureas synthesized in this way confirmed the reasonable substrate and functional group tolerance of our protocol.
Continuous-flow synthesis of thioureas, enabled by aqueous polysulfide solution
ábrányi-Balogh, Péter,Keser?, Gy?rgy M.,Mándity, István M.,Németh, András Gy.,Orsy, Gy?rgy,Szabó, Renáta
, (2021/06/25)
We have developed the continuous-flow synthesis of thioureas in a multicomponent reaction starting from isocyanides, amidines, or amines and sulfur. The aqueous polysulfide solution enabled the application of sulfur under homogeneous and mild conditions. The crystallized products were isolated by simple filtration after the removal of the co-solvent, and the sulfur retained in the mother liquid. Presenting a wide range of thioureas synthesized by this procedure confirms the utility of the convenient continuous-flow application of sulfur.
Gram Scalable Method to Synthesize Biscarbodiimides and Asymmetric Monocarbodiimides: A Platform to Access an Array of Phosphaguanidines, Amidines, and Guanidines
Bailey, Brad,Camelio, Andrew M.,Davis, Anna,Krasovskiy, Arkady
, (2021/11/12)
A mild, broadly functional group tolerant methodology has been developed to access a variety of mono- and bis-carbodiimides in good yield and high purity on multigram scale. Direct addition into these versatile motifs facilitated the rapid synthesis of a library of novel amidinines, guanidines, and phosphaguandines.
Pos [...] 4 group metal olefin polymerization catalyst
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Paragraph 0486-0487, (2019/08/27)
Embodiments are directed to phosphaguanidine metal complexes of formula I and using those complexes in α-olefin polymerization systems.
Cerium ammonium nitrate-catalyzed aerobic oxidative coupling of dithiocarbamates: Facile synthesis of thioureas and bis(aminothiocarbonyl)disulfides
Li, Tian-Tian,Song, Xiang-Hai,Wang, Mei-Shuang,Ma, Ning
, p. 40054 - 40060 (2014/12/10)
Diverse disubstituted and trisubstituted thioureas were synthesized by the condensation of dithiocarbamate TEA (or DABCO) salts and amines using cerium ammonium nitrate (CAN) as a catalyst in high yields at room temperature. It is a one-pot method and it is unnecessary to isolate isothiocyanates. This reaction probably took place through nucleophilic addition of amines to isothiocyanates, which were generated by oxidative coupling of dithiocarbamates and the following decomposition of bis(aminothiocarbonyl)disulfides. When secondary amines and CS2served as the reactants, bis(aminothiocarbonyl)disulfides were obtained via tandem nucleophilic addition/oxidative coupling reactions in moderate to excellent yields. In all the coupling reactions, the oxidant was air and CAN possibly acted as an SET catalyst.
Molecular determinants of ligand binding modes in the histamine H 4 receptor: Linking ligand-based three-dimensional quantitative structure-activity relationship (3D-QSAR) models to in silico guided receptor mutagenesis studies
Istyastono, Enade P.,Nijmeijer, Saskia,Lim, Herman D.,Van De Stolpe, Andrea,Roumen, Luc,Kooistra, Albert J.,Vischer, Henry F.,De Esch, Iwan J. P.,Leurs, Rob,De Graaf, Chris
experimental part, p. 8136 - 8147 (2012/01/05)
The histamine H4 receptor (H4R) is a G protein-coupled receptor (GPCR) that plays an important role in inflammation. Similar to the homologous histamine H3 receptor (H3R), two acidic residues in the H4/sub
A simple and green procedure for the synthesis of N-benzylthioureas
De Sequeira Aguiar, Lucia C.,Viana, Gil M.,Dos Santos Romualdo, Marcus V.,Costa, Marcio V.,Bonato, Bruno S.
experimental part, p. 540 - 544 (2012/06/01)
A simple and efficient reaction protocol for the synthesis of N-benzylthioureas is described from benzylisothiocyanate (BITC: 94% pure/GC-MS), isolated from crushed papaya seeds.
1-(Methyldithiocarbonyl)imidazole: A useful thiocarbonyl transfer reagent for synthesis of substituted thioureas
Mohanta, Pramod K.,Dhar, Sanchita,Samal,Ila,Junjappa
, p. 629 - 637 (2007/10/03)
1-(Methyldithiocarbonyl)imidazole 1 and its N-methyl quaternary salt 2 have been shown to be efficient methyldithiocarbonyl and thiocarbonyl transfer reagents for the synthesis of dithiocarbamates, symmetrical and unsymmetrical mono-, di- and tri-substituted thioureas in high yields under mild and simple non-hazardous reaction conditions. (C) 2000 Elsevier Science Ltd.
A convenient route to cyanoguanidines
Novak, Lajos,Hanania, Michel,Kovacs, Peter,Kovacs, Csilla Erika,Kolonits, Pal,Szantay, Csaba
, p. 1757 - 1766 (2007/10/03)
A facile and versatile method for the preparation of cyanoguanidines 7 from amines 3 and isothiocyanates 4 via a methylation, cyanamide-treatment sequence is described.
Studies on the Sructure of Some Derivatives of 1,3-Thiazolidine-2-thione and Δ2-1,3-Thiazoline-2-thiol
Fujita, Eiichi,Nagao, Yoshimitsu,Seno, Kaoru,Takao, Sachiko,Miyasaka, Tadayo,et al.
, p. 914 - 919 (2007/10/02)
Two types of reactions have been observed for the ambident anion of 1,3-thiazolidine-2-thione: regioselective N-acylation and S-alkylation.The structures of the products, amides and thioethers, were determined by X-ray crystallographic analysis and by ass
