78080-53-2Relevant academic research and scientific papers
Phosphine-Catalyzed [3 + 2] Annulation of Morita-Baylis-Hillman Carbonates with Isoxazole-Based Alkenes
Liao, Jianning,Dong, Jipan,Xu, Jiaqing,Wang, Wei,Wu, Yongjun,Hou, Yuxia,Guo, Hongchao
supporting information, p. 2090 - 2099 (2021/02/05)
A phosphine-catalyzed [3 + 2] annulation of Morita-Baylis-Hillman (MBH) carbonates with 3-methyl-4-nitro-5-styrylisoxazoles has been developed to afford various multifunctional isoxazoles in moderate to good yields with moderate to excellent diastereoselectivities. With a spirocyclic chiral phosphine as the catalyst, up to 89% ee was obtained.
Tandem grinding reactions involving aldol condensation and Michael addition in sequence for synthesis of 3,4,5-trisubstituted isoxazoles
Hu, Xiao-Mu,Dong, Hai,Li, Yue-Dan,Huang, Ping,Tian, Zhuang,Wang, Ping-An
, p. 27883 - 27887 (2019/09/30)
A one-pot, base-catalyzed, tandem grinding process involving carrying out aldol condensation and Michael addition in sequence to produce 3,4,5-trisubstituted isoxazoles from 3,5-dimethyl-4-nitroisoxazole, aromatic aldehydes and activated methylene compoun
An efficient solvent-free synthesis of 3-methyl-4-nitro-5-styrylisoxazoles using solid nano-titania
Dwivedi, Kartikey Dhar,Marri, Sameer Reddy,Nandigama, Satish Kumar,Chowhan, Raju L
, (2018/09/13)
Abstract: An efficient and solvent-free procedure for the synthesis of 3-methyl-4-nitro-5-styrylisoxazoles using nano-titania as solid support and recyclable catalyst is presented. This method provides clean, simple, solvent-free and useful alternative to
One-pot synthesis of functionalized isoxazole-thiolane hybrids via Knoevenagel condensation and domino sulfa-1,6-Michael/intramolecular vinylogous Henry reactions
Nagaraju, Sakkani,Satyanarayana, Neeli,Paplal, Banoth,Vasu, Anuji K.,Kanvah, Sriram,Sridhar, Balasubramanian,Sripadi, Prabhakar,Kashinath, Dhurke
, p. 94474 - 94478 (2015/11/17)
One-pot synthesis of highly functionalized tetrahydrothiophene (thiolane) derivatives conjugated with biologically useful isooxazole are reported via the Knoevenagel condensation followed by domino sulfa-1,6-Michael/intramolecular vinylogous Henry reactio
Organocatalyzed asymmetric vinylogous Michael addition of α,β-unsaturated γ-butyrolactam
Zhang, Jinlong,Liu, Xihong,Ma, Xiaojuan,Wang, Rui
, p. 9329 - 9331 (2013/10/01)
Highly efficient asymmetric vinylogous 1,6-Michael addition of α,β-unsaturated γ-butyrolactam to 3-methyl-4-nitro-5-alkenyl- isoxazoles and Michael addition to trichloromethyl ketones by using a chiral quinine-derived squaramide organocatalyst were described, giving products with high diastereo- and enantioselectivities (up to >25:1 dr and 96% ee).
Studies on the reactivity of 3-methyl-4-nitro-5-styrylisoxazoles with S-nucleophiles
Bruschi, Simone,Moccia, Maria,Adamo, Mauro F.A.
experimental part, p. 3602 - 3604 (2011/07/31)
We have investigated the reactivity of 3-methyl-4-nitro-5-styrylisoxazoles with S-nucleophiles. This study revealed that the title compounds were optimal Michael acceptors toward thiols. A procedure was also established to prepare isoxazole-containing sul
Multicomponent synthesis of spiroisoxazolines
Adamo, Mauro F. A.,Donati, Donato,Duffy, Eleanor F.,Sarti-Fantoni, Piero
, p. 8395 - 8399 (2007/10/03)
A three-component one-pot procedure (3-MCR) was developed to assemble the spiroisoxazoline nucleus from commercially available materials. This new methodology affords the title compounds in high yields and without the use of chromatography.
Michael additions on isoxazole derivatives under solvent-free conditions
Rajanarendar,Ramesh,Karunakar
, p. 1994 - 1996 (2007/10/03)
Knoevenagel condensation of 3,5-dimethyl-4-nitro-isoxazole 1 with aromatic aldehydes in solid state in the presence of piperidine gives 3-methyl-4-nitro-5-styryl-isoxazoles 2 in excellent yields within few minutes. Michael addition of active methylene com
