780807-69-4Relevant academic research and scientific papers
New substituted indolizines by 1,3-dipolar cycloaddition reactions. part 2. 7-cyanoindolizines
Dumitra?cu, Florea,Georgescu, Emilian,Georgescu, Florentina,Filip, Petru,Miu, Barbu,Dumitrescu, Dan G.
experimental part, p. 589 - 594 (2009/12/25)
The new indolizine derivatives 6a-e and 7a-e containing a cyano group grafted on the pyridinic ring were obtained by reaction of N-phenacylpyridinium bromides 3 with ethyl propiolate or l-butyn-3-one as acetylenic dipolarophiles in medium of 1,2-epoxypropane. Structural proof for the compounds was provided by elemental analysis and NMR spectroscopy, including COSY and HETCOR experiments.
