78088-45-6Relevant academic research and scientific papers
Activity of phosphino palladium(II) and platinum(II) complexes against HIV-1 and Mycobacterium tuberculosis
Gama, Ntombenhle H.,Elkhadir, Afag Y. F.,Gordhan, Bhavna G.,Kana, Bavesh D.,Darkwa, James,Meyer, Debra
, p. 637 - 650 (2016/08/13)
Treatment of human immunodeficiency virus (HIV) is currently complicated by increased prevalence of co-infection with Mycobacterium tuberculosis. The development of drug candidates that offer the simultaneous management of HIV and tuberculosis (TB) would
The synthesis of, and characterization of the dynamic processes occurring in Pd(ii) chelate complexes of 2-pyridyldiphenylphosphine
Liu, Jianke,Jacob, Chacko,Sheridan, Kelly J.,Al-Mosule, Firas,Heaton, Brian T.,Iggo, Jonathan A.,Matthews, Mark,Pelletier, Jeremie,Whyman, Robin,Bickley, Jamie F.,Steiner, Alexander
, p. 7921 - 7935 (2011/01/08)
Pd(ii) complexes in which 2-pyridyldiphenylphosphine (Ph2Ppy) chelates the Pd(ii) centre have been prepared and characterized by multinuclear NMR spectroscopy and by X-ray crystallographic analysis. trans- [Pd(κ1-Ph2Ppy)2Cl2] is transformed into [Pd(κ2-Ph2Ppy)(κ1- Ph2Ppy)Cl]Cl by the addition of a few drops of methanol to dichloromethane solutions, and into [Pd(κ2-Ph 2Ppy)(κ1-Ph2Ppy)Cl]X by addition of AgX or TlX, (X = BF4-, CF3SO3 - or MeSO3-). [Pd(κ1-Ph 2Ppy)2(p-benzoquinone)] can be transformed into [Pd(κ2-Ph2Ppy)(κ1-Ph 2Ppy)(MeSO3)][MeSO3] by the addition of two equivalents of MeSO3H. Addition of further MeSO3H affords [Pd(κ2-Ph2Ppy)(κ1-Ph 2PpyH)(MeSO3)][MeSO3]2. Addition of two equivalents of CF3SO3H, MeSO3H or CF 3CO2H and two equivalents of Ph2Ppy to [Pd(OAc)2] in CH2Cl2 or CH2Cl 2-MeOH affords [Pd(κ2-Ph2Ppy) (κ1-Ph2Ppy)X]X, (X = CF3SO 3-, MeSO3- or CF3CO 2-), however addition of two equivalents of HBF 4·Et2O affords a different complex, tentatively formulated as [Pd(κ2-Ph2Ppy)2]X 2. Addition of excess acid results in the clean formation of [Pd(κ2-Ph2Ppy)(κ1-Ph 2PpyH)(X)]X2. In methanol, addition of MeSO3H and three equivalents of Ph2Ppy to [Pd(OAc)2] affords [Pd(κ2-Ph2Ppy)(κ1-Ph 2Ppy)2][MeSO3]2 as the principal Pd-phosphine complex. The fluxional processes occuring in these complexes and in [Pd (κ1-Ph2Ppy)3Cl]X, (X = Cl, OTf) and the potential for hemilability of the Ph2Ppy ligand has been investigated by variable-temperature NMR. The activation entropy and enthalpy for the regiospecific fluxional processes occuring in [Pd(κ2- Ph2Ppy)(κ1-Ph2Ppy)2][MeSO 3]2 have been determined and are in the range -10 to -30 J mol-1 K-1 and ca. 30 kJ mol-1 respectively, consistent with associative pathways being followed. The observed regioselectivities of the exchanges are attributed to the constraints imposed by microscopic reversibility and the small bite angle of the Ph2Ppy ligand. X-Ray crystal structure determinations of trans-[Pd(κ1- Ph2Ppy)2Cl2], [Pd(κ2-Ph 2Ppy)(κ1-Ph2Ppy)Cl][BF4], [Pd(κ1-Ph2Ppy)2(p-benzoquinone)], trans-[Pd(κ1-Ph2PpyH)2Cl 2][MeSO3]2, and [Pd(κ1-Ph 2Ppy)3Cl](Cl) are reported. In [Pd(κ2- Ph2Ppy)(κ1-Ph2Ppy)Cl][BF4] a donor-acceptor interaction is seen between the pyridyl-N of the monodentate Ph2Ppy ligand and the phosphorus of the chelating Ph2Ppy resulting in a trigonal bipyramidal geometry at this phosphorus.
(Perfluoro)alkylsilyl-substituted 2-[bis(4-aryl)phosphino]pyridines: Synthesis and comparison of their palladium complexes in methoxycarbonylation of phenylacetylene in regular solvents and supercritical CO2
De Pater, Jeroen J. M.,Maljaars, C. Elizabeth P.,De Wolf, Elwin,Lutz, Martin,Spek, Anthony L.,Deelman, Berth-Jan,Elsevier, Cornelis J.,Van Koten, Gerard
, p. 5299 - 5310 (2008/10/09)
The synthesis and characterization of three new 2-[bis{4-(bromo)phenyl} phosphino]pyridine (8), 2-[bis{4-(trimethylsilyl)phenyl}phosphino]pyridine (9), and 2-[bis{4-((2-(perfluorohexyl)ethyl)dimethylsilyl)phenyl}phosphino]pyridine (10) ligands (L) is reported. The corresponding compounds trans-/cis-[PdCl 2(L)2] 11-13, trans-[PdCl(Me)(L)2] 14-16, and maleic anhydride complexes [Pd(L)2(cyclo-(-CH=CHC(O)OC(O)-)] 17 and 18 were synthesized and characterized. In the methoxycarbonylation of phenylacetylene in methanol catalysts derived from [Pd(OAc)2] as the palladium source with either 9 or 10 as ligand showed the same activity (TON = 4000, 50 min reaction time) and selectivity (about 98% for the branched product) as the catalyst obtained from [Pd(OAc)2] and 2-[diphenylphosphino] pyridine (2). Both 2 and 10 were also tested in this reaction using a 1:1 mixture of methanol and α,α′,α″-trifluorotoluene as solvent system: fluorous 10 generated a more active catalyst (TON = 3400 for 10 vs 3000 for 2). In supercritical CO2 the use of 10 as ligand (with [Pd-(OAc)2]) in this reaction gave a TON of 2000 (50 min reaction time) and a selectivity of >99% for the branched product. Nonfluorous [Pd(2)2(cyclo-(CH=CHC(O)OC(O)-)] gave a particularly active catalyst for the methoxycarbonylation of phenylacetylene (TON of about 8000, 50 min reaction time, TOF50 of about 30 000 mol phenylacetylene per mol Pd per hour in methanol) with no loss in selectivity (98% selectivity toward the branched product).
Mono- and dinuclear palladium complexes containing 2-pyridylphosphine ligands, including X-ray characterization of Pd2I2(μ-PPh2py)2 and a dimethylacetylenedicarboxylate A-frame complex Pd2Cl2(μ-Ppy3)2(μ-MeO2C-C=C-CO2Me); py = 2-pyridyl
Xie, Yun,Lee, Chung-Li,Yang, Yeping,Rettig, Steven J.,James, Brian R.
, p. 751 - 762 (2007/10/02)
Dibromo- and diiodopalladium(II) complexes are prepared by metathesis of cis-PdCl2(PPh3-npyn)2 species (n = 1-3) using the appropriate sodium halide; py = 2-pyridyl.NMR spectroscopy, particularly 13C, is use
Synthesis and Characterization of Palladium(II) and Platinum(II) Complexes Containing Monodentate Phosphorus Donating or Chelating 2-(Dimethylphosphino)pyridine (PMe2py)
Suzuki, Takayoshi,Kita, Masakazu,Kashiwabara, Kazuo,Fujita, Junnosuke
, p. 3434 - 3442 (2007/10/02)
The complexes (M=Pd(II), Pt(II); X=Cl, Br, and I) have been synthesized and characterized both in the solid state and in solution by their infrared and 1H, 13C, and 31P NMR spectra, in addition to an X-ray crystallographic analysis of cis-.The latter complex exists as a cis-trans equilibrium mixture in solution, while only the cis isomer has been isolated in the solid state.The complex which has been isolated as the trans isomer shows also the same isomerization in solution, in contrast to which exists only as the trans isomer both in the solid state and in solution.Furthermore, PMe2py has been found to have the ability for chelation via the nitrogen and phosphorus atoms to make a four-membered chelate ring.The chelate ring in the complexes -, PF6-) has been confirmed by infrared spectra and X-ray analysis of cis(P,P)-a chelating ligand.
Preparation of binuclear complexes using 2-(diphenylphosphino)pyridine as a bridging ligand. Synthesis of some ruthenium complexes and their interaction with palladium complexes
Maisonnet, Andre,Farr, James P.,Olmstead, Marilyn M.,Hunt, Catherine T.,Balch, Alan L.
, p. 3961 - 3967 (2008/10/08)
The reactions between Ru(Ph2Ppy)2(CO)3 and (1,5-cyclooctadiene)PdCl2 and between Ru(Ph2PPy)2(CO)2Cl2 and Pd2-(dibenzylideneacetone)3 have been examined as routes to binuclear Ru/Pd complexes. The first reaction produces Ru-(Ph2Ppy)2(CO)2Cl2, Ru(Ph2Ppy)(CO)2Cl2, Pd2(Ph2Ppy)2Cl2, and two isomers of RuPd(Ph2Ppy)2(CO)2Cl2, while the second forms predominantly the two binuclear products. Syntheses of Ru3(CO)9(Ph2Ppy)3, Ru(Ph2Ppy)2(CO)3, and Ru-(Ph2Ppy)2(CO)2Cl2 from Ru3(CO)12 are reported as are the preparations of Pd(Ph2Ppy)2Cl2 and Pd2(Ph2Ppy)2Cl2. All new compounds have been characterized by infrared spectroscopy and 31P{1H} NMR spectroscopy. The two isomers of RuPd(Ph2Ppy)2(CO)2Cl2 interconvert on heating in solution. The structure of one isomer has been determined unambiguously by X-ray crystallography. RuPd(Ph2Ppy)2(CO)2Cl2 crystallizes in the space group P21/c with cell dimensions (determined at 140 K) of a = 10.493 (2) ?, b = 17.685 (4) ?, c = 21.470 (5) ?, β = 92.07 (2)°, Z = 4, and V = 3982 (1) ?3. The structure was refined by blocked cascade least-squares to a conventional R value of 0.043 by using 4605 significant reflections. The compound possesses a Pd-Ru bond with a distance of 2.660 (1) ?. The palladium atom is four-coordinate with a Ru, Cl, P, N donor set, while the ruthenium atom is six-coordinate with a Pd, Cl, P, N, C2 donor set.
