781-97-5

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-CHLOROPHENYL)-2,2,3,3,3-PENTAFLUORO-PROPAN-1-ONE is used as an intermediate in organic synthesis for the development of new pharmaceutical compounds. Its unique structure and reactivity make it a promising candidate for creating drugs with desired properties.
Used in Agrochemical Industry:
In the agrochemical sector, 1-(4-CHLOROPHENYL)-2,2,3,3,3-PENTAFLUORO-PROPAN-1-ONE serves as a key intermediate in the synthesis of novel agrochemicals. Its chemical properties allow for the development of new compounds with potential applications in pest control and crop protection.
Used in Materials Science:
1-(4-CHLOROPHENYL)-2,2,3,3,3-PENTAFLUORO-PROPAN-1-ONE is utilized as a building block in the creation of advanced materials with specific properties. Its fluorinated ketone structure lends itself to the development of materials with enhanced performance characteristics for various applications.
Used in Research and Development:
1-(4-CHLOROPHENYL)-2,2,3,3,3-PENTAFLUORO-PROPAN-1-ONE is also used in research and development for the exploration of new drugs and materials. The interesting chemical properties and reactivity of 1-(4-CHLOROPHENYL)-2,2,3,3,3-PENTAFLUORO-PROPAN-1-ONE make it a valuable tool for scientists and researchers working on innovative projects in the fields of pharmaceuticals, agrochemicals, and materials science.

InChI:InChI=1/C9H4ClF5O/c10-6-3-1-5(2-4-6)7(16)8(11,12)9(13,14)15/h1-4H

Upstream product

• 422-64-0 pentafluoropropionic acid 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 122-01-0 4-chloro-benzoyl chloride 

Downstream Products

• 6919-61-5 N-methoxy-N-methylbenzamide 
• 76435-59-1 1-(4-Chloro-phenyl)-2,3,3,3-tetrafluoro-propan-1-one 
• 1579-58-4 1-(4-chlorophenyl)-2,2,3,3,3-pentafluoropropan-1-ol 

Relevant academic research and scientific papers

Photoredox Fluoroalkylation of Arylidene and Alkylidene Amidrazones

A method for the photoredox fluoroalkylation of the C–H bond of azomethine compounds obtained from condensation of aldehydes and N-methylpyrrolidinone-derived amidrazones is described. The reactions are promoted with a carbazole-based organic photocatalyst under blue light irradiation. The ability of the cyclic nitrogen to stabilize a nitrogen-centered radical is believed to be a key factor responsible for the reaction efficiency.

Well-defined CuC2F5 complexes and pentafluoroethylation of acid chlorides

Four new well-defined CuI complexes bearing a C2F5 ligand have been prepared and fully characterized: [(Ph3P)2CuC2F5] (2), [(bpy)CuC2F5] (3), [(Ph3P)Cu(phen)C2F5] (4), and [(IPr)CuC2F5] (5). X-ray structures of all four have been determined, showing that the C2F5-ligated Cu atom can be di- (5), tri- (2 and 3), and tetracoordinate (4). The mixed phen-PPh3 complex 4 is a highly efficient fluoroalkylating agent for a broad variety of acid chlorides. This high-yielding transformation represents the first general method for the synthesis of RCOC2F5 from the corresponding RCOCl. Four well-defined CuC2F5 complexes have been prepared and fully characterized, with [(phen)Cu(PPh3)C2F5] (phen=1,10-phenanthroline) proving to be a remarkably efficient fluoroalkylating agent for a broad variety of acid chlorides (see scheme). The procedure represents the first general method for the one-step conversion of RCOCl into valuable pentafluoroethyl ketones.

FLUORIDE ION CATALYZED ISOMERIZATION OF 2-ARYL-F-BUTENES

A kinetic study of the fluoride ion catalyzed isomerization of a series of 2-aryl-F-1-butenes shows the reactions to be pseudo first order in olefin at constant fluoride ion concentration.The resultant Hammett plot is non-linear with a concave downward br