78115-08-9

Upstream product

• 124-41-4 sodium methylate 
• 78115-06-7 (3R)-3-benzyloxycarbonylamino-3-methoxy-1-(1-methoxycarbonyl-2-methylprop-1-enyl)-2-azetidinone 
• 90497-69-1 ((2R,3S)-2-Benzenesulfinyl-3-methoxy-4-oxo-azetidin-3-yl)-carbamic acid benzyl ester 
• 90497-68-0 [(3S,4R)-1-(tert-Butyl-dimethyl-silanyl)-3-methoxy-2-oxo-4-phenylsulfanyl-azetidin-3-yl]-carbamic acid benzyl ester 
• 90581-08-1 [(3S,4R)-1-(tert-Butyl-dimethyl-silanyl)-2-oxo-4-phenylsulfanyl-azetidin-3-yl]-carbamic acid benzyl ester 
• 501-53-1 benzyl chloroformate 

Relevant academic research and scientific papers

The efficient synthesis of chiral key intermediates for monobactam antibiotics

Chemical asymmetric syntheses of the key intermediates (4,6,8) for the synthesis of monobactam antibiotics (SQ 26776 (azthreonam, sulfazecin, and SQ 26180) are accomplished from (±)-4-phenylsulfonyl-2-azetidinone.

Synthesis and antibacterial activity of 3-acylamino-3-methoxy-2-azetidinone-1-sulfonic acid derivatives

As a key intermediate for the synthesis of sulfazecin derivatives, 3-amino-3-methoxy-2-azetidinone (24 or 26) was synthesized from penicillins, and various new compounds, including sulfazecin, were synthesized by acylation and sulfonation of 24 or 26. Som