78131-94-9

Upstream product

• 75-15-0 carbon disulfide 
• 16738-00-4 2-(4-bromophenoxy)acetic acid hydrazide 
• 6964-29-0 ethyl 2-(4-bromophenoxy)acetate 
• 106-41-2 4-bromo-phenol 
• 57676-50-3 2-(4-bromophenyl)acetohydrazide 

Downstream Products

• 120353-38-0 5-(4-bromophenoxy)methyl-3-(2-chlorophenyl)aminomethyl-1,3,4-oxadiazole-2-thione 
• 120353-42-6 5-(4-bromophenoxy)methyl-3-(2-ethoxyphenyl)aminomethyl-1,3,4-oxadiazole-2-thione 
• 120353-39-1 5-(4-bromophenoxy)methyl-3-(4-chlorophenyl)aminomethyl-1,3,4-oxadiazole-2-thione 
• 120353-41-5 5-(4-bromophenoxy)methyl-3-(2-methoxyphenyl)aminomethyl-1,3,4-oxadiazole-2-thione 
• 120353-43-7 5-(4-bromophenoxy)methyl-3-(2,5-dimethylphenyl)aminomethyl-1,3,4-oxadiazole-2-thione 

Relevant academic research and scientific papers

Reactions of α-Halo Ketones with 5-Benzyl-and 5-Phenoxymethyl-2H,3H-1,3,4-oxadiazole-2-thiones

Alkylation of 5-substituted 2H,3H-1,3,4-oxadiazole-3-thiones with α-bromo ketones in alkaline solutions yields 5-substituted 2-aroylmethylthio-1,3,4-oxadiazoles; in acidic solutions these compounds re-arrange into 4-aryl-3-arylacetamido-2H,3H-1,3-thiazol-2-ones.

Synthesis, Characterization, Spectral and Antifungal Properties of Some 5-Substituted-1,3,4-oxadiazole-2-thiones and Their Mannich Bases

A series of 5-substituted aryloxymethyl-1,3,4-oxadiazole-2-thione (3a-e) and their Mannich bases 4-8 are synthesized and subjected to fungitoxic screening.The structures of these compounds are established on the basis of elemental analysis 1H-n.m.r. and mass spectral data.The mass spectral fragmentation pathways of these compounds are discussed.