78134-75-5Relevant academic research and scientific papers
AN EXPLANATION FOR THE FAILURE OF AMINOMETHANESULFONIC ACID TO FORM SULFONAMIDES. ACYL CHLORIDE-PROMOTED GENERATION OF α-CARBOXAMIDOALKYLATING ELECTROPHILES.
Moe, Gregory R.,Sayre, Lawrence M.,Portoghese, Philip S.
, p. 537 - 540 (2007/10/02)
Attempted N,N-dibenzoylation of aminomethanesulfonic acid results in C-S bond cleavage, generating synthetically useful α-benzamidomethylating electrophiles.The importance of this observation in regard to the reported failures to prepare sulfonamide analogs of peptides is discussed.
