78155-76-7

Usage

Uses

Used in Pharmaceutical Industry:
5-Nitroindazole-3-carboxylic acid is used as a potential anti-inflammatory agent for its ability to modulate inflammatory responses and alleviate symptoms associated with inflammation.
5-Nitroindazole-3-carboxylic acid is also used as a potential anti-cancer agent, given its capacity to target and inhibit the growth of cancer cells, making it a candidate for further research and development in oncology.
Used in Organic Synthesis:
5-Nitroindazole-3-carboxylic acid serves as a building block in organic synthesis, where its unique functional groups can be utilized to create a variety of complex organic molecules for different applications.
Used in Chemical Research:
In the field of chemical research, 5-Nitroindazole-3-carboxylic acid is used to study its reactivity and properties, contributing to the understanding of indazole derivatives and their potential applications in various chemical processes.

InChI:InChI=1/C8H5N3O4/c12-8(13)7-5-3-4(11(14)15)1-2-6(5)9-10-7/h1-3H,(H,9,10)(H,12,13)

Upstream product

• 28284-09-5 2-(5-nitro-2-oxoindolin-3-ylidene)hydrazinecarbothioamide 
• 4498-67-3 1H-Indazole-3-carboxylic acid 

Downstream Products

• 885278-45-5 5-amino-3-ethoxycarbonyl-1H-indazole 
• 660412-02-2 5-nitro-1H-indazole-3-carboxylic acid (4-methylsulphamoylmethylphenyl)-amide 
• 78155-75-6 methyl 5-nitro-1H-indazole-3-carboxylate 
• 908247-75-6 (5-amino-1H-indazol-3-yl)methanol 
• 1093064-20-0 C₃₁H₂₃N₅O₂ 
• 1093066-24-0 C₃₁H₂₅N₅ 
• 1093064-69-7 3-(1-methyl-1H-pyrazol-3-yl)-5-nitro-1-trityl-1H-indazole 
• 1093064-19-7 1-(5-nitro-1-trityl-1H-indazol-3-yl)-propynone 
• 1093064-18-6 5-nitro-1-trityl-1H-indazole-3-carboxylic acid methoxy-methyl-amide 
• 1093064-17-5 5-nitro-1-trityl-1H-indazole-3-carboxylic acid 
• 1093064-16-4 5-nitro-1-trityl-1H-indazole-3-carboxylic acid methyl ester 
• 1360893-27-1 7-nitro-1H-indazole-3-carboxylic acid methyl ester 
• 78155-85-8 3-ethoxycarbonyl-5-nitro-1H-indazole 
• 78155-77-8 5-amino-1H-indazole-3-carboxylic acid 

Relevant academic research and scientific papers

1H-INDAZOLE-3-CARBOXAMIDE COMPOUNDS AS MAPKAP KINASE MODULATORS

The invention provides compounds of the formula: (I) for use in the prophylaxis or treatment of a disease state or condition mediated by a MAPKAP kinase: wherein A is a bond or a group CH2; R1 is a carbocyclic or heterocyclic group having from 3 to 12 ring members; R3, R4, R5 and R6 are the same or different and are each selected from hydrogen, halogen, hydroxy, trifluoromethyl, cyano, nitro, carboxy, amino, carbocyclic and heterocyclic groups having from 3 to 12 ring members; a group Ra -Rbwherein Ra is a bond, 0, CO, X1C(X2), C(X2)Xl, X1C(X2)X1, S, SO, S02, NRc, SO2NRc or NRcS02; and Rb is selected from hydrogen, carbocyclic and heterocyclic groups having from 3 to 12 ring members, and a C1-8 hydrocarbyl group optionally substituted by one or more substituents selected from hydroxy, oxo, halogen, cyano, nitro, amino, mono or di-C1-4 hydrocarbylamino, carbocyclic and heterocyclic groups having from 3 to 12 ring members and wherein one or more carbon atoms of the C1-8 hydrocarbyl group may optionally be replaced by 0, S, SO, SO2, NRc, X1C(X2), C(X2)X1 or X1C(X2)X1; Rc is hydrogen or C1-4hydrocarbyl; and X1 is O, S or NRc and X2 is =O, =S or =NRc.

SEMICARBAZONES AND THIOSEMICARBAZONES OF THE HETEROCYCLIC SERIES

When heated with an aqueous solution of potassium carbonate, 5-nitroisatin 3-thiosemicarbazone does not form 8-nitro-1,2,4-triazinoindole-3-thione, as indicated earlier, but forms 6-(2-amino-5-nitrophenyl)-5-oxo-1,2,4-triazine-3-thione and 5-nitro-