78158-32-4Relevant articles and documents
Z-2-(2-acyl methylene) thiazolidine-4-ketone derivative as well as preparation method and application thereof
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Paragraph 0036; 0042-0045, (2021/08/11)
The invention relates to the field of chemical synthesis, in particular to Z-2-(2-acyl methylene) thiazolidine-4-ketone derivatives as well as a preparation method and application thereof. The structural formula of the Z-2-(2-acyl methylene) thiazolidine-
Regio- and Diastereoselective Access to 4-Imidazolidinones via an Aza-Mannich Initiated Cyclization of Sulfamate-Derived Cyclic Imines with α-Halo Hydroxamates
Zhou, Jing,Zhang, Hong,Chen, Xue-Lian,Qu, Ya-Li,Zhu, Qianqian,Feng, Chen-Guo,Chen, Ya-Jing
, p. 9179 - 9187 (2019/08/12)
An efficient regio- and diastereoselective cyclization of sulfamate-derived cyclic imines with unsubstituted or monosubstituted α-halo hydroxamates is developed under mild conditions. This reaction proceeds smoothly under transition-metal-free conditions via a domino aza-Mannich addition/intramolecular nucleophilic substitution sequence, providing a convenient route to access 2-monosubstituted and 2,5-disubstituted 4-imidazolidinones. Notably, the products were obtained with single trans-isomers in moderate to excellent yields.