781657-63-4

Upstream product

• 781657-62-3 phenyl 2,4,6-tri-O-acetyl-1-thio-α/β-L-idopyranose 
• 22331-19-7 3-O-benzyl-1,2-O-isopropylidene-5,6-di-O-mesyl-α-D-glucofuranose 
• 37776-17-3 5,6-anhydro-3-O-benzyl-1,2-O-isopropylidene-β-L-idofuranose 
• 18685-18-2 3-O-benzyl-1,2-5,6-O-diisopropylidene-α-D-glucofuranose 
• 118711-49-2 1,2,4,6-tetra-O-acetyl-3-O-benzyl-L-idopyranoside 
• 84563-90-6 6-O-acetyl-3-O-benzyl-1,2-O-isopropylidene-5-O-methanesulfonyl-α-D-glucofuranose 
• 18006-25-2 3-O-benzyl-1,2-O-isopropylidene-α-D-glucofuranose diacetate 
• 22529-61-9 (1R)-1-((3aR,6S,6aR)-6-(benzyloxy)-2,2-dimethyltetrahydrofuro(2,3-d)(1,3)dioxol-5-yl)ethane-1,2-diol 

Downstream Products

• 781657-64-5 (2R,4aS,7R,8R,8aR)-8-Benzyloxy-2-phenyl-6-phenylsulfanyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol 
• 735326-98-4 phenyl 3-O-benzyl-4,6-O-benzylidene-1-thio-α-L-idopyranoside 
• 735327-19-2 phenyl 3-O-benzyl-4,6-O-benzylidene-1-thio-β-L-idopyranoside 
• 850637-33-1 phenyl 2-O-benzoyl-3-O-benzyl-1-thio-α-L-idopyranosyluronic acid 
• 175978-41-3 phenyl 2-O-benzoyl-3-O-benzyl-4,6-dihydroxylthio-α-L-idopyranoside 
• 616876-73-4 methyl (phenyl 2-O-benzoyl-3-O-benzyl-1-thio-α-L-idopyranoside)uronate 
• 735327-00-1 phenyl 2-O-acetyl-3-O-benzyl-4,6-O-benzylidene-1-thio-α-L-idopyranoside 
• 735327-12-5 3-O-(2-O-acetyl-α-L-idopyranosyl)-2,5-anhydro-1,6-di-O-benzoyl-D-mannitol 
• 781657-66-7 C₃₄H₄₆O₁₃Si 
• 735327-02-3 3-O-(2-O-acetyl-3-O-benzyl-4,6-O-benzylidene-α-L-idopyranosyl)-2,5-anhydro-1,6-di-O-benzoyl-D-mannitol 
• 735327-10-3 3-O-(2-O-acetyl-3,4-di-O-benzoyl-α-L-idopyranosyl)-2,5-anhydro-1,4,6-tri-O-benzoyl-D-mannitol 
• 767287-62-7 2,5-anhydro-1,4,6-tri-O-benzoyl-3-O-(2-O-acetyl-3,4-di-O-benzoyl-α-L-idopyranosyluronic acid)-D-mannitol 
• 735327-07-8 3-O-(2-O-acetyl-3,4-di-O-benzoyl-6-O-t-butyldimethylsilyl-α-L-idopyranosyl)-2,5-anhydro-1,4,6-tri-O-benzoyl-D-mannitol 
• 781657-65-6 Acetic acid (2R,4aS,7R,8S,8aR)-8-benzyloxy-2-phenyl-6-phenylsulfanyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester 

Relevant academic research and scientific papers

A modular strategy toward the synthesis of heparin-like oligosaccharides using monomeric building blocks in a sequential glycosylation strategy

A novel flexible assembly strategy is described for the modular synthesis of heparin and heparan sulfates. The reported strategy uses monomeric building bocks to construct the oligosaccharide chain to attain a maximum degree of flexibility. In the assembly, 1-hydroxyl glucosazido- and 1-thio uronic acid donors are combined in a sequential glycosylation protocol using sulfonium triflate activator systems. The key 1-thio uronic acids were obtained in an efficient manner from diacetone glucose employing a chemo- and regioselective oxidation of partially protected glucose and idose thioglycosides.

Synthesis of a polysulfated heparin degradation product

Two suitable methods for the synthesis of the heparin degradation product 2,5-anyhydro-3-O-(α-L-ido-pyranosyluronate)-D-mannitol hexa O-sulfate are reported. The synthesis pathways start from D-glucose and D-glucosamine.