78174-93-3

Basic information

• Product Name: 2(1H)-Pyrazinone, 1-methyl-5-phenyl-
• CAS NO: 78174-93-3
• Molecular Formula: C11H10N2O
• Molecular Weight: 186.213
• Mol File: 78174-93-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2(1H)-Pyrazinone, 1-methyl-5-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Pyrazinone, 1-methyl-5-phenyl-(78174-93-3)
• EPA Substance Registry System: 2(1H)-Pyrazinone, 1-methyl-5-phenyl-(78174-93-3)

Safety Data

• Hazardous Substances Data: 78174-93-3(Hazardous Substances Data)

Upstream product

• 25844-72-8 6-phenyl-3(2H)-pyridazinone 
• 77-78-1 dimethyl sulfate 
• 25844-72-8 2-hydroxy-5-phenylpyrazine 

Downstream Products

• 78174-96-6 5-Methyl-8-phenyl-2,3-dioxa-5,7-diaza-bicyclo[2.2.2]oct-7-en-6-one 
• 78174-96-6 (1S,4S)-5-Methyl-8-phenyl-2,3-dioxa-5,7-diaza-bicyclo[2.2.2]oct-7-en-6-one 

Relevant articles and documents

C?H Methylation of Iminoamido Heterocycles with Sulfur Ylides**

The direct methylation of N-heterocycles is an important transformation for the advancement of pharmaceuticals, agrochemicals, functional materials, and other chemical entities. Herein, the unprecedented C(sp2)-H methylation of iminoamido heterocycles as nucleoside base analogues is described. Notably, trimethylsulfoxonium salt was employed as a methylating agent under aqueous conditions. A wide substrate scope and excellent level of functional-group tolerance were attained. Moreover, this method can be readily applied to the site-selective methylation of azauracil nucleosides. The feasibility of gram-scale reactions and various transformations of the products highlight the synthetic potential of the developed method. Combined deuterium-labeling experiments aided the elucidation of a plausible reaction mechanism.